PMID- 101594
OWN - NLM
STAT- MEDLINE
DCOM- 19790115
LR  - 20051117
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 121
IP  - 5
DP  - 1978 Nov
TI  - Preparation of an alloantiserum to murine C3 and demonstration of multiple
      alleles.
PG  - 2025-9
AB  - An antiserum was produced in C3H/He mice that can recognize the antigenic
      variations of murine C3. The alloantiserum is directed to the gene product of one
      of the alleles (C3-1a allele) of the C3-1 locus that controls genetic variations 
      of murine C3 and is linked to H-2. The antiserum formed a single precipitin line 
      in the Ouchterlony test with sera obtained from mice that carry the C3-1a/a or
      C3-1a/b genotype, but it did not react with sera from mice that do not have C3
      coded for by the C3-1a allele. By the use of the alloantiserum, we detected a new
      C3 allotype (C3-1 CC) in SWR/J mice. The C3-1 CC is distinct from the other two
      allotypes on the basis of antigenicity and isoelectric point (pI). Therefore, at 
      least three alleles have been identified for the C3-1 locus.
FAU - Natsuume-Sakai, S
AU  - Natsuume-Sakai S
FAU - Amano, S
AU  - Amano S
FAU - Hayakawa, J I
AU  - Hayakawa JI
FAU - Takahashi, M
AU  - Takahashi M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Complement C3)
RN  - 0 (Immune Sera)
RN  - 0 (Isoantibodies)
SB  - AIM
SB  - IM
MH  - *Alleles
MH  - Animals
MH  - *Complement C3/genetics
MH  - Crosses, Genetic
MH  - *Immune Sera
MH  - Immunodiffusion
MH  - *Isoantibodies
MH  - Isoelectric Focusing
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Phenotype
MH  - Polymorphism, Genetic
EDAT- 1978/11/01 00:00
MHDA- 1978/11/01 00:01
CRDT- 1978/11/01 00:00
PHST- 1978/11/01 00:00 [pubmed]
PHST- 1978/11/01 00:01 [medline]
PHST- 1978/11/01 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1978 Nov;121(5):2025-9.