PMID- 101590
OWN - NLM
STAT- MEDLINE
DCOM- 19790115
LR  - 20101118
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 121
IP  - 5
DP  - 1978 Nov
TI  - Macrophage sensitivity to endotoxin: genetic control by a single codominant gene.
PG  - 1664-70
AB  - The effects of LPS on macrophages in vitro have been examined. LPS triggers
      macrophages to produce LAF and PGE2 in vitro. LPS is also cytotoxic for
      macrophages derived from LPS-sensitive mice and will significantly inhibit their 
      phagocytic ability. Both LAF production and cytotoxicity are due to the direct
      effects of LPS on the macrophage and do not require the particpation of
      lymphocytes. Each of these functions is abnormal in C3H/HeJ mice. The nature of
      the gene(s) controlling these macrophage responses to LPS has been determined.
      The response of (C3H/HeJ X C3H/HeN)F1 macrophages was intermediate when compared 
      to the parental responses and no sex linkage was found. Backcross linkage
      analysis suggested that the same autosomal codominant gene controls both
      macrophage and B lymphocyte-LPS sensitivity.
FAU - Rosenstreich, D L
AU  - Rosenstreich DL
FAU - Vogel, S N
AU  - Vogel SN
FAU - Jacques, A R
AU  - Jacques AR
FAU - Wahl, L M
AU  - Wahl LM
FAU - Oppenheim, J J
AU  - Oppenheim JJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Endotoxins)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Prostaglandins E)
SB  - AIM
SB  - IM
MH  - Animals
MH  - Cytotoxicity, Immunologic
MH  - Endotoxins/*pharmacology
MH  - *Escherichia coli
MH  - Female
MH  - Genes, Dominant
MH  - *Genes, MHC Class II
MH  - Genetic Linkage
MH  - Lipopolysaccharides/pharmacology
MH  - Lymphocytes/immunology
MH  - Macrophages/*immunology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Prostaglandins E/biosynthesis
EDAT- 1978/11/01 00:00
MHDA- 1978/11/01 00:01
CRDT- 1978/11/01 00:00
PHST- 1978/11/01 00:00 [pubmed]
PHST- 1978/11/01 00:01 [medline]
PHST- 1978/11/01 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1978 Nov;121(5):1664-70.