PMID- 1013503
OWN - NLM
STAT- MEDLINE
DCOM- 19770331
LR  - 20190902
IS  - 0080-0015 (Print)
IS  - 0080-0015 (Linking)
IP  - 57
DP  - 1976
TI  - Steroid receptor proteins and regulation of growth in mammary tumors.
PG  - 121-42
AB  - The failure of the estrogen receptor test to predict unequivocally whether a
      breast cancer will respond to endocrine therapy has prompted us to re-examine the
      spectrum of responses that might be expected in a hormone-sensitive tissue. Three
      basic responses are recognized; initiation of DNA synthesis and cell
      proliferation; negative feedback; and autophagia. The expression of these
      responses may be partly or totally deficient in tumors. In some tumors,
      resistance to hormone may result from the lack of entry of hormone into the
      nucleus; in others the interaction of hormone with chromatin is probably abnormal
      Evidence is presented in support of the idea that the presence of steroid in the 
      nucleus is strongly correlated to the presence of cytoplasmic receptor. The
      results also suggest that there is a strong link between the presence of steroid 
      in the nucleus and the initiation of DNA synthesis. Finally the disappearance of 
      nuclear receptor and the onset of autophagia seem to be related catabolic events.
FAU - Bruchovsky, N
AU  - Bruchovsky N
FAU - Van Doorn, E
AU  - Van Doorn E
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Recent Results Cancer Res
JT  - Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans 
      les recherches sur le cancer
JID - 0044671
RN  - 0 (Androgens)
RN  - 0 (Chromatin)
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Hormones)
RN  - 0 (Receptors, Androgen)
RN  - 0 (Receptors, Estrogen)
SB  - IM
MH  - Androgens/metabolism
MH  - Animals
MH  - Breast Neoplasms/*metabolism/physiopathology/therapy
MH  - Cell Division
MH  - Cell Nucleus/metabolism
MH  - Chromatin/metabolism
MH  - Cytoplasm/metabolism
MH  - DNA, Neoplasm/biosynthesis
MH  - Disease Models, Animal
MH  - Feedback
MH  - Female
MH  - Genes
MH  - Hormones/therapeutic use
MH  - Humans
MH  - Male
MH  - Mammary Neoplasms, Experimental/metabolism
MH  - Mice
MH  - Prostate/physiology
MH  - Rats
MH  - Receptors, Androgen
MH  - *Receptors, Estrogen
MH  - Regeneration
MH  - Testis/physiology
EDAT- 1976/01/01 00:00
MHDA- 1976/01/01 00:01
CRDT- 1976/01/01 00:00
PHST- 1976/01/01 00:00 [pubmed]
PHST- 1976/01/01 00:01 [medline]
PHST- 1976/01/01 00:00 [entrez]
AID - 10.1007/978-3-642-81043-5_11 [doi]
PST - ppublish
SO  - Recent Results Cancer Res. 1976;(57):121-42. doi: 10.1007/978-3-642-81043-5_11.