PMID- 10102815
OWN - NLM
STAT- MEDLINE
DCOM- 19990422
LR  - 20220331
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 284
IP  - 5411
DP  - 1999 Apr 2
TI  - Two distinct cytokines released from a human aminoacyl-tRNA synthetase.
PG  - 147-51
AB  - Aminoacyl-tRNA synthetases catalyze aminoacylation of transfer RNAs (tRNAs). It
      is shown that human tyrosyl-tRNA synthetase can be split into two fragments with 
      distinct cytokine activities. The endothelial monocyte-activating polypeptide
      II-like carboxy-terminal domain has potent leukocyte and monocyte chemotaxis
      activity and stimulates production of myeloperoxidase, tumor necrosis
      factor-alpha, and tissue factor. The catalytic amino-terminal domain binds to the
      interleukin-8 type A receptor and functions as an interleukin-8-like cytokine.
      Under apoptotic conditions in cell culture, the full-length enzyme is secreted,
      and the two cytokine activities can be generated by leukocyte elastase, an
      extracellular protease. Secretion of this tRNA synthetase may contribute to
      apoptosis both by arresting translation and producing needed cytokines.
FAU - Wakasugi, K
AU  - Wakasugi K
AD  - The Skaggs Institute for Chemical Biology, The Scripps Research Institute,
      Beckman Center, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
FAU - Schimmel, P
AU  - Schimmel P
LA  - eng
GR  - GM23562/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Antigens, CD)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-8)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (Receptors, Interleukin)
RN  - 0 (Receptors, Interleukin-8A)
RN  - 0 (Recombinant Proteins)
RN  - 0 (small inducible cytokine subfamily E, member 1)
RN  - EC 3.4.21.37 (Leukocyte Elastase)
RN  - EC 6.1.1.1 (Tyrosine-tRNA Ligase)
SB  - IM
CIN - Science. 1999 Apr 2;284(5411):63-4. PMID: 10215533
MH  - Amino Acid Sequence
MH  - Antigens, CD/metabolism
MH  - Apoptosis
MH  - Binding, Competitive
MH  - Catalytic Domain
MH  - Chemotaxis, Leukocyte
MH  - *Cytokines
MH  - Humans
MH  - Interleukin-8/*metabolism/pharmacology
MH  - Leukocyte Elastase/metabolism
MH  - Molecular Sequence Data
MH  - Monocytes/physiology
MH  - Neoplasm Proteins/*metabolism/pharmacology
MH  - Neutrophils/metabolism/physiology
MH  - RNA-Binding Proteins/*metabolism/pharmacology
MH  - Receptors, Interleukin/metabolism
MH  - Receptors, Interleukin-8A
MH  - Recombinant Proteins/metabolism
MH  - Signal Transduction
MH  - Tumor Cells, Cultured
MH  - Tyrosine-tRNA Ligase/chemistry/*metabolism/pharmacology
EDAT- 1999/04/02 00:00
MHDA- 1999/04/02 00:01
CRDT- 1999/04/02 00:00
PHST- 1999/04/02 00:00 [pubmed]
PHST- 1999/04/02 00:01 [medline]
PHST- 1999/04/02 00:00 [entrez]
AID - 10.1126/science.284.5411.147 [doi]
PST - ppublish
SO  - Science. 1999 Apr 2;284(5411):147-51. doi: 10.1126/science.284.5411.147.