PMID- 10102270
OWN - NLM
STAT- MEDLINE
DCOM- 19990427
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 96
IP  - 6
DP  - 1999 Mar 19
TI  - Hedgehog controls limb development by regulating the activities of distinct
      transcriptional activator and repressor forms of Cubitus interruptus.
PG  - 819-31
AB  - Hedgehog (Hh) proteins play diverse organizing roles in development by regulating
      gene expression in responding cells. The Gli homolog Cubitus interruptus (Ci) is 
      involved in controlling the transcription of Hh target genes. A repressor form of
      Ci arises in the absence of Hh signaling by proteolytic cleavage of intact Ci. We
      show that this cleavage is essential for limb patterning and is regulated by Hh
      in vivo. We provide evidence for the existence of a distinct activator form of
      Ci, which does not arise by mere prevention of Ci proteolysis, but rather depends
      on a separate regulatory step subject to Hh control. These different activities
      of Ci regulate overlapping but distinct subsets of Hh target genes. Thus, limb
      development is organized by the integration of different transcriptional outputs 
      of Hh signaling.
FAU - Methot, N
AU  - Methot N
AD  - Zoologisches Institut, Universitat Zurich, Switzerland.
FAU - Basler, K
AU  - Basler K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (En protein, Drosophila)
RN  - 0 (Hedgehog Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Insect Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (ci protein, Drosophila)
RN  - 0 (dpp protein, Drosophila)
RN  - 149291-21-4 (hh protein, Drosophila)
RN  - EC 3.4.- (Endopeptidases)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - DNA-Binding Proteins/*genetics/metabolism
MH  - Drosophila/*embryology
MH  - *Drosophila Proteins
MH  - Endopeptidases/metabolism
MH  - Extremities/embryology
MH  - Gene Expression Regulation, Developmental
MH  - Hedgehog Proteins
MH  - Homeodomain Proteins/genetics/metabolism
MH  - Insect Proteins/genetics/*metabolism
MH  - Repressor Proteins/*genetics/metabolism
MH  - Trans-Activators/*genetics/metabolism
MH  - Transcription Factors/genetics/metabolism
MH  - Transcription, Genetic
MH  - Transgenes
EDAT- 1999/04/02 00:00
MHDA- 1999/04/02 00:01
CRDT- 1999/04/02 00:00
PHST- 1999/04/02 00:00 [pubmed]
PHST- 1999/04/02 00:01 [medline]
PHST- 1999/04/02 00:00 [entrez]
AID - S0092-8674(00)80592-9 [pii]
AID - 10.1016/s0092-8674(00)80592-9 [doi]
PST - ppublish
SO  - Cell. 1999 Mar 19;96(6):819-31. doi: 10.1016/s0092-8674(00)80592-9.