PMID- 10102269
OWN - NLM
STAT- MEDLINE
DCOM- 19990427
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 96
IP  - 6
DP  - 1999 Mar 19
TI  - Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a
      repellent for olfactory bulb axons.
PG  - 807-18
AB  - The olfactory bulb plays a central role in olfactory information processing
      through its connections with both peripheral and cortical structures. Axons
      projecting from the olfactory bulb to the telencephalon are guided by a repulsive
      activity in the septum. The molecular nature of the repellent is not known. We
      report here the isolation of vertebrate homologs of the Drosophila slit gene and 
      show that Slit protein binds to the transmembrane protein Roundabout (Robo). Slit
      is expressed in the septum whereas Robo is expressed in the olfactory bulb.
      Functionally, Slit acts as a chemorepellent for olfactory bulb axons. These
      results establish a ligand-receptor relationship between two molecules important 
      for neural development, suggest a role for Slit in olfactory bulb axon guidance, 
      and reveal the existence of a new family of axon guidance molecules.
FAU - Li, H S
AU  - Li HS
AD  - Department of Anatomy and Neurobiology, Washington University School of Medicine,
      St. Louis, Missouri 63110, USA.
FAU - Chen, J H
AU  - Chen JH
FAU - Wu, W
AU  - Wu W
FAU - Fagaly, T
AU  - Fagaly T
FAU - Zhou, L
AU  - Zhou L
FAU - Yuan, W
AU  - Yuan W
FAU - Dupuis, S
AU  - Dupuis S
FAU - Jiang, Z H
AU  - Jiang ZH
FAU - Nash, W
AU  - Nash W
FAU - Gick, C
AU  - Gick C
FAU - Ornitz, D M
AU  - Ornitz DM
FAU - Wu, J Y
AU  - Wu JY
FAU - Rao, Y
AU  - Rao Y
LA  - eng
GR  - R01 CA114197-01A2/CA/NCI NIH HHS/United States
GR  - R01 EY014576-03/EY/NEI NIH HHS/United States
GR  - R01 GM070967-02/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Drosophila Proteins)
RN  - 0 (Ligands)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (roundabout protein)
RN  - 0 (sli protein, Drosophila)
SB  - IM
MH  - Animals
MH  - Axons/*physiology
MH  - Cell Line
MH  - Cell Membrane/metabolism
MH  - *Drosophila Proteins
MH  - Gene Expression
MH  - Humans
MH  - Ligands
MH  - Mice
MH  - Nerve Tissue Proteins/metabolism/*physiology
MH  - Olfactory Bulb/cytology
MH  - Receptors, Immunologic/*metabolism
MH  - Solubility
MH  - Telencephalon
MH  - Xenopus
EDAT- 1999/04/02 00:00
MHDA- 1999/04/02 00:01
CRDT- 1999/04/02 00:00
PHST- 1999/04/02 00:00 [pubmed]
PHST- 1999/04/02 00:01 [medline]
PHST- 1999/04/02 00:00 [entrez]
AID - S0092-8674(00)80591-7 [pii]
AID - 10.1016/s0092-8674(00)80591-7 [doi]
PST - ppublish
SO  - Cell. 1999 Mar 19;96(6):807-18. doi: 10.1016/s0092-8674(00)80591-7.