PMID- 10102037
OWN - NLM
STAT- MEDLINE
DCOM- 19990415
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 433
IP  - 2
DP  - 1999 Mar 10
TI  - Molecular cloning, expression and chromosomal localisation of the mouse Rev3l
      gene, encoding the catalytic subunit of polymerase zeta.
PG  - 109-16
AB  - The REV3 gene of Saccharomyces cerevisiae encodes the catalytic subunit of DNA
      polymerase zeta which is involved in translesion synthesis. The mouse homolog of 
      this gene, Rev3l, was cloned and sequenced. The gene encodes a putative protein
      of 3122 amino acids. The sequence conservation to its yeast counterpart is
      restricted to several regions. In the carboxy-terminal part of the protein all
      six domains are present that are characteristic for alpha-type DNA polymerases.
      In the amino-terminal part of the protein two regions can be identified with
      considerable similarity to the NT boxes of mouse polymerase delta. In addition, a
      region of 60 residues unique for the REV3 homologs can be found in the middle
      part of the protein. The mouse REV3L protein shows strong sequence conservation
      with the recently cloned human REV3L protein (86% identity overall). Northern
      blot analysis of various tissues of the mouse revealed that transcription of the 
      Rev3l gene was highest in brain, ovaries and testis. The human REV3L gene was
      localised to the long arm of chromosome 6, region 21-22. The mouse equivalent
      maps to chromosome 10, distal to the c-myb gene, close to the Macs gene.
FAU - Van Sloun, P P
AU  - Van Sloun PP
AD  - Department of Radiation Genetics and Chemical Mutagenesis-MGC, Leiden University 
      Medical Center, Sylvius Laboratory, Netherlands.
FAU - Romeijn, R J
AU  - Romeijn RJ
FAU - Eeken, J C
AU  - Eeken JC
LA  - eng
SI  - GENBANK/AF083464
SI  - GENBANK/AF083465
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (DNA, Complementary)
RN  - EC 2.7.7.7 (DNA-Directed DNA Polymerase)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Catalytic Domain
MH  - *Chromosome Mapping
MH  - Cloning, Molecular
MH  - DNA, Complementary
MH  - DNA-Directed DNA Polymerase/*genetics/metabolism
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Mice
MH  - Molecular Sequence Data
MH  - Sequence Homology, Amino Acid
EDAT- 1999/04/02 00:00
MHDA- 1999/04/02 00:01
CRDT- 1999/04/02 00:00
PHST- 1999/04/02 00:00 [pubmed]
PHST- 1999/04/02 00:01 [medline]
PHST- 1999/04/02 00:00 [entrez]
AID - S0921-8777(98)00067-6 [pii]
AID - 10.1016/s0921-8777(98)00067-6 [doi]
PST - ppublish
SO  - Mutat Res. 1999 Mar 10;433(2):109-16. doi: 10.1016/s0921-8777(98)00067-6.