PMID- 10101687
OWN - NLM
STAT- MEDLINE
DCOM- 19990609
LR  - 20180822
IS  - 0818-9641 (Print)
IS  - 0818-9641 (Linking)
VI  - 77
IP  - 1
DP  - 1999 Feb
TI  - Targeted disruption of caspase genes in mice: what they tell us about the
      functions of individual caspases in apoptosis.
PG  - 58-63
AB  - Cysteine proteases of the caspase family are crucial mediators of apoptosis. All 
      mammalian cells contain a large number of caspases. Although many caspases are
      activated in a cell committed to apoptosis, recent data from caspase gene
      knockout mice suggest that individual caspases may be involved in the cell and
      stimulus-specific pathways of cell death. The gene disruption studies also
      establish the functional hierarchy between two structurally distinct classes of
      caspases. The present review discusses these recent findings and elaborates on
      how these mutant mouse models have helped the understanding of the mechanisms
      that govern programmed cell death in the immune and other systems.
FAU - Colussi, P A
AU  - Colussi PA
AD  - Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science,
      Adelaide, Australia.
FAU - Kumar, S
AU  - Kumar S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Immunol Cell Biol
JT  - Immunology and cell biology
JID - 8706300
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cytokines)
RN  - 0 (Fadd protein, mouse)
RN  - 0 (Fas-Associated Death Domain Protein)
RN  - EC 3.4.22.- (Casp8 protein, mouse)
RN  - EC 3.4.22.- (Casp9 protein, mouse)
RN  - EC 3.4.22.- (Caspase 2)
RN  - EC 3.4.22.- (Caspase 8)
RN  - EC 3.4.22.- (Caspase 9)
RN  - EC 3.4.22.- (Caspases)
SB  - IM
MH  - *Adaptor Proteins, Signal Transducing
MH  - Animals
MH  - Apoptosis/immunology/*physiology
MH  - Carrier Proteins/genetics/physiology
MH  - Caspase 2
MH  - Caspase 8
MH  - Caspase 9
MH  - Caspases/genetics/*physiology
MH  - Cytokines/metabolism
MH  - Enzyme Activation
MH  - Fas-Associated Death Domain Protein
MH  - Mice
MH  - Mice, Knockout
MH  - Mitochondria/metabolism
MH  - Models, Biological
MH  - Protein Processing, Post-Translational
RF  - 46
EDAT- 1999/04/02 00:00
MHDA- 1999/04/02 00:01
CRDT- 1999/04/02 00:00
PHST- 1999/04/02 00:00 [pubmed]
PHST- 1999/04/02 00:01 [medline]
PHST- 1999/04/02 00:00 [entrez]
AID - 10.1046/j.1440-1711.1999.00788.x [doi]
PST - ppublish
SO  - Immunol Cell Biol. 1999 Feb;77(1):58-63. doi: 10.1046/j.1440-1711.1999.00788.x.