PMID- 10100858
OWN - NLM
STAT- MEDLINE
DCOM- 19990420
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 446
IP  - 2-3
DP  - 1999 Mar 12
TI  - Identification and characterization of a 14 kDa human protein as a novel
      parvulin-like peptidyl prolyl cis/trans isomerase.
PG  - 278-82
AB  - A second member of the parvulin family of peptidyl-prolyl cis/trans isomerases
      was identified in a human lung cDNA library. The gene encoded a protein named
      hPar14 that has 131 amino acid residues and a molecular mass of 13676 Da.
      Sequence comparison showed 34.5% identity to E. coli Par10 and 34% identity to
      human Pin1 (hPar18) within a C-terminal region of 87 or 120 amino acid residues, 
      respectively. In comparison to the E. coli Par10, hPar14 possesses a N-terminal
      extension of 41 amino acid residues. This extension does not contain a
      polyproline II helix-binding motif typical of the known eukaryotic parvulins. The
      hPar14 does not accelerate the cis to trans interconversion of oligopeptides with
      side chain-phosphorylated Ser(Thr)-Pro moieties as hPin1 did. In contrast, it
      showed preference of an arginine residue adjacent N-terminal to proline. Northern
      blot analysis revealed expression of the gene within various human tissues like
      heart, placenta, liver, kidney and pancreas.
FAU - Uchida, T
AU  - Uchida T
AD  - Max-Planck Research Unit, Enzymology of Protein Folding, Halle/Saale, Germany.
FAU - Fujimori, F
AU  - Fujimori F
FAU - Tradler, T
AU  - Tradler T
FAU - Fischer, G
AU  - Fischer G
FAU - Rahfeld, J U
AU  - Rahfeld JU
LA  - eng
SI  - GENBANK/AB009690
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (DNA, Complementary)
RN  - 0 (Escherichia coli Proteins)
RN  - 0 (NIMA-Interacting Peptidylprolyl Isomerase)
RN  - EC 5.2.1.8 (PIN1 protein, human)
RN  - EC 5.2.1.8 (Peptidylprolyl Isomerase)
RN  - EC 5.2.1.8 (parvA protein, E coli)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - DNA, Complementary
MH  - Escherichia coli Proteins
MH  - Humans
MH  - Molecular Sequence Data
MH  - NIMA-Interacting Peptidylprolyl Isomerase
MH  - Peptidylprolyl Isomerase/*genetics
MH  - Sequence Homology, Amino Acid
EDAT- 1999/04/01 00:00
MHDA- 1999/04/01 00:01
CRDT- 1999/04/01 00:00
PHST- 1999/04/01 00:00 [pubmed]
PHST- 1999/04/01 00:01 [medline]
PHST- 1999/04/01 00:00 [entrez]
AID - S0014-5793(99)00239-2 [pii]
AID - 10.1016/s0014-5793(99)00239-2 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Mar 12;446(2-3):278-82. doi: 10.1016/s0014-5793(99)00239-2.