PMID- 10100614
OWN - NLM
STAT- MEDLINE
DCOM- 19990507
LR  - 20191210
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 446
IP  - 1
DP  - 1999 Mar 5
TI  - Hypoxia increases the association of 4E-binding protein 1 with the initiation
      factor 4E in isolated rat hepatocytes.
PG  - 55-9
AB  - Incubation of hepatocytes under hypoxia increases binding of translation
      initiation factor eIF-4E to its inhibitory regulator 4E-BP1, and this correlates 
      with dephosphorylation of 4E-BP1. Rapamycin induced the same effect in aerobic
      cells but no additive effect was observed when hypoxic cells were treated with
      rapamycin. This enhanced association of 4E-BP1 with eIF-4E might be mediated by
      mTOR. Nevertheless, only hypoxia produces a rapid inhibition of protein
      synthesis. Although hypoxia might be signalling via the rapamycin-sensitive
      pathway by changing eIF-4E availability, such a pathway is unlikely to be
      responsible for the depression in overall protein synthesis under hypoxia.
FAU - Tinton, S A
AU  - Tinton SA
AD  - Unite de Biochimie Toxicologique et Cancerologique, Universite Catholique de
      Louvain, Brussels, Belgium.
FAU - Buc-Calderon, P M
AU  - Buc-Calderon PM
LA  - eng
PT  - Journal Article
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Antifungal Agents)
RN  - 0 (Carrier Proteins)
RN  - 0 (Eif4ebp1 protein, rat)
RN  - 0 (Eukaryotic Initiation Factor-4E)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Peptide Initiation Factors)
RN  - 0 (Phosphoproteins)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Animals
MH  - Antifungal Agents/pharmacology
MH  - *Carrier Proteins
MH  - Cell Hypoxia
MH  - Cells, Cultured
MH  - Eukaryotic Initiation Factor-4E
MH  - Intracellular Signaling Peptides and Proteins
MH  - Liver/*metabolism/pathology
MH  - Male
MH  - Peptide Initiation Factors/*metabolism
MH  - Phosphoproteins/*metabolism
MH  - Phosphorylation
MH  - Rats
MH  - Rats, Wistar
MH  - Signal Transduction
MH  - Sirolimus/pharmacology
EDAT- 1999/04/01 00:00
MHDA- 1999/04/01 00:01
CRDT- 1999/04/01 00:00
PHST- 1999/04/01 00:00 [pubmed]
PHST- 1999/04/01 00:01 [medline]
PHST- 1999/04/01 00:00 [entrez]
AID - S0014-5793(99)00185-4 [pii]
AID - 10.1016/s0014-5793(99)00185-4 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Mar 5;446(1):55-9. doi: 10.1016/s0014-5793(99)00185-4.