PMID- 10100603
OWN - NLM
STAT- MEDLINE
DCOM- 19990507
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 446
IP  - 1
DP  - 1999 Mar 5
TI  - The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link
      between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a
      novel actor of DNA repair?
PG  - 6-8
AB  - Poly(ADP-ribose)polymerase is a nuclear NAD-dependent enzyme and an essential
      nick sensor involved in cellular processes where nicking and rejoining of DNA
      strands are required. The inter-alpha-inhibitor family is comprized of several
      plasma proteins that all harbor one or more so-called heavy chains designated
      H1-H4. The latter originate from precursor polypeptides H1P-H4P whose upper two
      thirds are highly homologous. We now describe a novel protein that includes (i) a
      so-called BRCT domain found in many proteins involved in DNA repair, (ii) an area
      that is homologous to the NAD-dependent catalytic domain of
      poly(ADP-ribose)polymerase, (iii) an area that is homologous to the upper two
      thirds of precursor polypeptides H1P-H4P and (iv) a proline-rich region with a
      potential nuclear localization signal. This protein now designated PH5P points to
      as yet unsuspected links between poly(ADP-ribose)polymerase and the
      inter-alpha-inhibitor family and is likely to be involved in DNA repair.
FAU - Jean, L
AU  - Jean L
AD  - INSERM Unit-78 and Institut Federatif de Recherches Multidisciplinaires sur les
      Peptides, Rouen, France.
FAU - Risler, J L
AU  - Risler JL
FAU - Nagase, T
AU  - Nagase T
FAU - Coulouarn, C
AU  - Coulouarn C
FAU - Nomura, N
AU  - Nomura N
FAU - Salier, J P
AU  - Salier JP
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Alpha-Globulins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (PARP4 protein, human)
RN  - 39346-44-6 (inter-alpha-inhibitor)
RN  - EC 2.4.2.30 (Poly(ADP-ribose) Polymerases)
SB  - IM
MH  - Alpha-Globulins/genetics/*metabolism
MH  - Animals
MH  - *DNA Repair
MH  - Humans
MH  - Nuclear Proteins/*metabolism
MH  - Poly(ADP-ribose) Polymerases/*metabolism
RF  - 19
EDAT- 1999/04/01 00:00
MHDA- 1999/04/01 00:01
CRDT- 1999/04/01 00:00
PHST- 1999/04/01 00:00 [pubmed]
PHST- 1999/04/01 00:01 [medline]
PHST- 1999/04/01 00:00 [entrez]
AID - S0014-5793(99)00173-8 [pii]
AID - 10.1016/s0014-5793(99)00173-8 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Mar 5;446(1):6-8. doi: 10.1016/s0014-5793(99)00173-8.