PMID- 10099707
OWN - NLM
STAT- MEDLINE
DCOM- 19990526
LR  - 20161122
IS  - 0066-4278 (Print)
IS  - 0066-4278 (Linking)
VI  - 61
DP  - 1999
TI  - Electrogenic Na+/HCO3- cotransporters: cloning and physiology.
PG  - 699-723
AB  - Bicarbonate and CO2 comprise the major pH buffer of biological fluids. In the
      renal proximal tubule most of the filtered HCO3- is reabsorbed by an electrogenic
      Na/HCO3 cotransporter located at the basolateral membrane. This Na+ bicarbonate
      cotransporter (NBC) was recently cloned. This review highlights the recent
      developments leading to and since the cloning of NBC: NBC expression cloning,
      protein features, clone physiology, isoforms and genes, mRNA distribution, and
      protein distribution. With the NBC amino acid sequence 30-35% identical to the
      anion exchangers (AE1-3), a superfamily of HCO3- transporters is emerging.
      Physiologically, NBC is electrogenic, Na+ dependent, HCO3- dependent, Cl-
      independent, and inhibited by stilbenes (DIDS and SITS). NBC clones and proteins 
      have been isolated from several tissues (other than kidney) thought to have
      physiologically distinct HCO3- transporters. For example, NBC occurs in pancreas,
      prostate, brain, heart, small and large intestine, stomach, and epididymis.
      Finally, there are at least two genes that encode NBC proteins. Possible future
      directions of research are discussed.
FAU - Romero, M F
AU  - Romero MF
AD  - Department of Physiology and Biophysics and Pharmacology, Case Western Reserve
      University School of Medicine, Cleveland, Ohio 44106-4790, USA. mfr2@po.cwru.edu
FAU - Boron, W F
AU  - Boron WF
LA  - eng
GR  - F32 DK009342-02/DK/NIDDK NIH HHS/United States
GR  - DK30344/DK/NIDDK NIH HHS/United States
GR  - F32 DK009342-03/DK/NIDDK NIH HHS/United States
GR  - DK17433/DK/NIDDK NIH HHS/United States
GR  - F32 DK009342-01/DK/NIDDK NIH HHS/United States
GR  - DK43171/DK/NIDDK NIH HHS/United States
GR  - F32 DK009342/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Annu Rev Physiol
JT  - Annual review of physiology
JID - 0370600
RN  - 0 (Carrier Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Sodium-Bicarbonate Symporters)
SB  - IM
MH  - Amino Acid Sequence/genetics
MH  - Animals
MH  - Carrier Proteins/genetics/*physiology
MH  - Cloning, Molecular
MH  - Electrophysiology
MH  - Humans
MH  - Molecular Sequence Data
MH  - RNA, Messenger/metabolism
MH  - Sodium-Bicarbonate Symporters
MH  - Tissue Distribution
RF  - 96
EDAT- 1999/04/01 00:00
MHDA- 1999/04/01 00:01
CRDT- 1999/04/01 00:00
PHST- 1999/04/01 00:00 [pubmed]
PHST- 1999/04/01 00:01 [medline]
PHST- 1999/04/01 00:00 [entrez]
AID - 10.1146/annurev.physiol.61.1.699 [doi]
PST - ppublish
SO  - Annu Rev Physiol. 1999;61:699-723. doi: 10.1146/annurev.physiol.61.1.699.