PMID- 10098882
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20190630
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 72
IP  - 4
DP  - 1999 Apr
TI  - Transcriptional regulation of mouse type 1 inositol 1,4,5-trisphosphate receptor 
      gene by NeuroD-related factor.
PG  - 1717-24
AB  - The type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) is a Ca2+ channel
      protein that is expressed abundantly in the CNS, such as in the cerebellar
      Purkinje cells and hippocampus. We previously demonstrated that the box-I
      element, which is located -334 relative to the transcription initiation site of
      the mouse IP3R1 gene and includes an E-box consensus sequence, is involved in the
      up-regulation of such IP3R1 gene expression. Furthermore, the previous study also
      indicated that some CNS-related basic helix-loop-helix (bHLH) factors bind to the
      box-I and activate IP3R1 gene expression. In this study, we demonstrated that one
      of the CNS-related bHLH factors, neuronal differentiation factor (NeuroD)-related
      factor (NDRF), specifically bound to the box-I sequence with a ubiquitously
      expressed bHLH protein, E47, and activated IP3R1 gene expression. In situ
      hybridization of adult mouse brain revealed that IP3R1 and NDRF mRNA were
      co-expressed in many subsets of neurons, highly in Purkinje cells and hippocampus
      and moderately in cerebral cortex, olfactory bulb, and caudate putamen.
      Furthermore, the spatiotemporal expression patterns of these two genes resembled 
      one another throughout postnatal development of the mouse CNS. From these
      results, we suggest that NDRF is involved in the tissue-specific regulation of
      IP3R1 gene expression in the CNS.
FAU - Konishi, Y
AU  - Konishi Y
AD  - Department of Biology, Faculty of Science, Chiba University, Japan.
FAU - Ohkawa, N
AU  - Ohkawa N
FAU - Makino, Y
AU  - Makino Y
FAU - Ohkubo, H
AU  - Ohkubo H
FAU - Kageyama, R
AU  - Kageyama R
FAU - Furuichi, T
AU  - Furuichi T
FAU - Mikoshiba, K
AU  - Mikoshiba K
FAU - Tamura, T
AU  - Tamura T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (Calcium Channels)
RN  - 0 (DNA Probes)
RN  - 0 (Inositol 1,4,5-Trisphosphate Receptors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurod2 protein, mouse)
RN  - 0 (Neurod2 protein, rat)
RN  - 0 (Neuropeptides)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 169238-82-8 (NeuroD protein)
SB  - IM
MH  - Animals
MH  - Basic Helix-Loop-Helix Transcription Factors
MH  - Brain/growth & development/physiology
MH  - Brain Chemistry/*genetics
MH  - Calcium Channels/*genetics
MH  - DNA Probes
MH  - Gene Expression Regulation, Developmental/physiology
MH  - Helix-Loop-Helix Motifs/physiology
MH  - In Situ Hybridization
MH  - Inositol 1,4,5-Trisphosphate Receptors
MH  - Mice
MH  - Nerve Tissue Proteins/*metabolism
MH  - Neuropeptides/metabolism
MH  - PC12 Cells
MH  - Promoter Regions, Genetic/physiology
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Receptors, Cytoplasmic and Nuclear/*genetics
MH  - Transcriptional Activation/*physiology
EDAT- 1999/03/31 00:00
MHDA- 1999/03/31 00:01
CRDT- 1999/03/31 00:00
PHST- 1999/03/31 00:00 [pubmed]
PHST- 1999/03/31 00:01 [medline]
PHST- 1999/03/31 00:00 [entrez]
AID - 10.1046/j.1471-4159.1999.721717.x [doi]
PST - ppublish
SO  - J Neurochem. 1999 Apr;72(4):1717-24. doi: 10.1046/j.1471-4159.1999.721717.x.