PMID- 10098325
OWN - NLM
STAT- MEDLINE
DCOM- 19990524
LR  - 20191024
IS  - 0167-5699 (Print)
IS  - 0167-5699 (Linking)
VI  - 20
IP  - 2
DP  - 1999 Feb
TI  - Multiple gamma c-dependent cytokines regulate T-cell development.
PG  - 71-6
AB  - Mutations in the common gamma chain (gamma c) of cytokine receptors account for
      human X-linked severe combined immunodeficiency disease. gamma c contributes to
      ligand binding and signaling as a component of five cytokine receptors:
      interleukin-2-receptor (IL-2R), IL-4R, IL-7R, IL-9R and IL-15R. Here, Thomas
      Malek and colleagues discuss the contribution of individual gamma c-dependent
      cytokines in both conventional and intraepithelial T-cell development.
FAU - Malek, T R
AU  - Malek TR
AD  - Dept of Microbiology and Immunology, University of Miami School of Medicine, FL
      33136, USA. tmalek@mednet.med.miami.edu
FAU - Porter, B O
AU  - Porter BO
FAU - He, Y W
AU  - He YW
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Immunol Today
JT  - Immunology today
JID - 8008346
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Interleukins)
RN  - 0 (Receptors, Antigen, T-Cell, gamma-delta)
RN  - 0 (Receptors, Cytokine)
RN  - 0 (Receptors, Interleukin)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/pharmacology/toxicity
MH  - Cell Differentiation
MH  - Hematopoiesis/genetics/*physiology
MH  - Humans
MH  - Interleukins/*physiology
MH  - Mice
MH  - Mice, Knockout
MH  - Models, Immunological
MH  - Receptors, Antigen, T-Cell, gamma-delta/analysis
MH  - Receptors, Cytokine/deficiency/genetics/*physiology
MH  - Receptors, Interleukin/chemistry/genetics/*physiology
MH  - Severe Combined Immunodeficiency/genetics/immunology/*pathology
MH  - T-Lymphocyte Subsets/*immunology/pathology
MH  - Thymus Gland/*pathology
MH  - X Chromosome/genetics
RF  - 55
EDAT- 1999/03/31 00:00
MHDA- 1999/03/31 00:01
CRDT- 1999/03/31 00:00
PHST- 1999/03/31 00:00 [pubmed]
PHST- 1999/03/31 00:01 [medline]
PHST- 1999/03/31 00:00 [entrez]
AID - S0167569998013917 [pii]
AID - 10.1016/s0167-5699(98)01391-7 [doi]
PST - ppublish
SO  - Immunol Today. 1999 Feb;20(2):71-6. doi: 10.1016/s0167-5699(98)01391-7.