PMID- 10097140
OWN - NLM
STAT- MEDLINE
DCOM- 19990512
LR  - 20220309
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 7
DP  - 1999 Mar 30
TI  - The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its
      expression is altered in multiple human tumors.
PG  - 3928-33
AB  - Alterations of human chromosome 8p occur frequently in many tumors. We identified
      a 1.5-Mb common region of allelic loss on 8p22 by allelotype analysis. cDNA
      selection allowed isolation of several genes, including FEZ1. The predicted Fez1 
      protein contained a leucine-zipper region with similarity to the DNA-binding
      domain of the cAMP-responsive activating-transcription factor 5. RNA blot
      analysis revealed that FEZ1 gene expression was undetectable in more than 60% of 
      epithelial tumors. Mutations were found in primary esophageal cancers and in a
      prostate cancer cell line. Transcript analysis from several FEZ1-expressing
      tumors revealed truncated mRNAs, including a frameshift. Alteration and
      inactivation of the FEZ1 gene may play a role in various human tumors.
FAU - Ishii, H
AU  - Ishii H
AD  - Kimmel Cancer Institute, Jefferson Medical College, Thomas Jefferson University, 
      Philadelphia, PA 19107, USA.
FAU - Baffa, R
AU  - Baffa R
FAU - Numata, S I
AU  - Numata SI
FAU - Murakumo, Y
AU  - Murakumo Y
FAU - Rattan, S
AU  - Rattan S
FAU - Inoue, H
AU  - Inoue H
FAU - Mori, M
AU  - Mori M
FAU - Fidanza, V
AU  - Fidanza V
FAU - Alder, H
AU  - Alder H
FAU - Croce, C M
AU  - Croce CM
LA  - eng
SI  - GENBANK/AF123652
SI  - GENBANK/AF123653
SI  - GENBANK/AF123654
SI  - GENBANK/AF123655
SI  - GENBANK/AF123656
SI  - GENBANK/AF123657
SI  - GENBANK/AF123658
SI  - GENBANK/AF123659
GR  - CA39860/CA/NCI NIH HHS/United States
GR  - CA51083/CA/NCI NIH HHS/United States
GR  - CA56336/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (FEZ1 protein, human)
RN  - 0 (LZTS1 protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Suppressor Proteins)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Breast Neoplasms/genetics
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 8
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/biosynthesis/chemistry/*genetics
MH  - Esophageal Neoplasms/genetics
MH  - Female
MH  - Gene Library
MH  - *Genes, Tumor Suppressor
MH  - Humans
MH  - Leucine Zippers
MH  - *Loss of Heterozygosity
MH  - Male
MH  - Molecular Sequence Data
MH  - Neoplasms/*genetics
MH  - Nerve Tissue Proteins
MH  - Ovarian Neoplasms/genetics
MH  - Prostatic Neoplasms/genetics
MH  - RNA, Messenger/analysis
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Testis/metabolism
MH  - *Transcription, Genetic
MH  - Tumor Cells, Cultured
MH  - *Tumor Suppressor Proteins
PMC - PMC22397
EDAT- 1999/03/31 00:00
MHDA- 1999/03/31 00:01
CRDT- 1999/03/31 00:00
PHST- 1999/03/31 00:00 [pubmed]
PHST- 1999/03/31 00:01 [medline]
PHST- 1999/03/31 00:00 [entrez]
AID - 10.1073/pnas.96.7.3928 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3928-33. doi: 10.1073/pnas.96.7.3928.