PMID- 10097068
OWN - NLM
STAT- MEDLINE
DCOM- 19990512
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 7
DP  - 1999 Mar 30
TI  - SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended
      isoform that is more related to the nuclear receptor corepressor.
PG  - 3519-24
AB  - SMRT (silencing mediator for retinoid and thyroid hormone receptors) and N-CoR
      (nuclear receptor copressor) mediate transcriptional repression of important
      regulators that are involved in many signaling pathways. SMRT and N-CoR are
      related proteins that form complexes with mSin3A/B and histone deacetylases to
      induce local chromatin condensation and transcriptional repression. However, SMRT
      is substantially smaller than N-CoR, lacking an N-terminal domain of
      approximately 1,000 aa that are present in N-CoR. Here, we report the
      identification of SMRT-extended (SMRTe), which contains an N-terminal sequence
      that shows striking similarity with N-CoR. As in N-CoR, this SMRTe-N-terminal
      domain also represses basal transcription. We find that SMRTe expression is
      regulated during cell cycle progression and SMRTe transcripts are present in many
      embryonic tissues. These data redefine a structurally and functionally more
      related nuclear receptor corepressor family and suggest an additional role for
      SMRTe in the regulation of cycle-specific gene expression in diverse signaling
      pathways.
FAU - Park, E J
AU  - Park EJ
AD  - Departments of Pharmacology and Molecular Toxicology, Molecular Cell Biology and 
      Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655,
      USA.
FAU - Schroen, D J
AU  - Schroen DJ
FAU - Yang, M
AU  - Yang M
FAU - Li, H
AU  - Li H
FAU - Li, L
AU  - Li L
FAU - Chen, J D
AU  - Chen JD
LA  - eng
SI  - GENBANK/AF125671
SI  - GENBANK/AF125672
GR  - R01 DK052542/DK/NIDDK NIH HHS/United States
GR  - DK52542/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (NCOR1 protein, human)
RN  - 0 (NCOR2 protein, human)
RN  - 0 (Ncor1 protein, mouse)
RN  - 0 (Ncor2 protein, mouse)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Nuclear Receptor Co-Repressor 1)
RN  - 0 (Nuclear Receptor Co-Repressor 2)
RN  - 0 (Protein Isoforms)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Repressor Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/chemistry/*genetics/*metabolism
MH  - Gene Library
MH  - HeLa Cells
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nuclear Proteins/chemistry/*metabolism
MH  - Nuclear Receptor Co-Repressor 1
MH  - Nuclear Receptor Co-Repressor 2
MH  - Protein Isoforms/chemistry/genetics/metabolism
MH  - Recombinant Proteins/biosynthesis/chemistry/metabolism
MH  - Repressor Proteins/chemistry/*genetics/*metabolism
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Transcription, Genetic
MH  - Transfection
PMC - PMC22325
EDAT- 1999/03/31 00:00
MHDA- 1999/03/31 00:01
CRDT- 1999/03/31 00:00
PHST- 1999/03/31 00:00 [pubmed]
PHST- 1999/03/31 00:01 [medline]
PHST- 1999/03/31 00:00 [entrez]
AID - 10.1073/pnas.96.7.3519 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3519-24. doi: 10.1073/pnas.96.7.3519.