PMID- 10094488
OWN - NLM
STAT- MEDLINE
DCOM- 19990420
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 445
IP  - 2-3
DP  - 1999 Feb 26
TI  - Identification of novel interaction partners for the conserved membrane proximal 
      region of alpha-integrin cytoplasmic domains.
PG  - 351-5
AB  - The alpha3Abeta1 integrin is a laminin receptor with a broad specificity for
      different laminin isoforms. Furthermore, it regulates the function of other
      integrins, like alpha2beta1, alpha5beta1 and alpha6Abeta1. In a yeast two hybrid 
      screen of a human placenta cDNA library, we identified cDNAs coding for four
      different proteins that strongly interact with the conserved region of the
      cytoplasmic domain of the alpha3A integrin subunit. In addition to the cDNA for
      nucleotide exchange factor Mss4 and the putative tumour suppressor protein BIN1, 
      two novel cDNAs were identified. Association analysis with different integrin
      subunits revealed them as cDNAs that encode binding proteins which react with a
      broad spectrum of alpha subunits. The conserved membrane proximal region of the
      alpha3A chain was identified as the binding site for all four proteins. They,
      therefore, may be involved in the regulation of general functions of integrins.
FAU - Wixler, V
AU  - Wixler V
AD  - Institute for Biochemistry II, Medical Faculty of the University of Cologne,
      Germany.
FAU - Laplantine, E
AU  - Laplantine E
FAU - Geerts, D
AU  - Geerts D
FAU - Sonnenberg, A
AU  - Sonnenberg A
FAU - Petersohn, D
AU  - Petersohn D
FAU - Eckes, B
AU  - Eckes B
FAU - Paulsson, M
AU  - Paulsson M
FAU - Aumailley, M
AU  - Aumailley M
LA  - eng
SI  - GENBANK/AJ131720
SI  - GENBANK/AJ131721
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Antigens, CD)
RN  - 0 (DNA, Complementary)
RN  - 0 (Integrin alpha3)
RN  - 0 (Integrins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antigens, CD/*genetics/metabolism
MH  - Base Sequence
MH  - Binding Sites
MH  - Cell Line
MH  - Cytoplasm/metabolism
MH  - DNA, Complementary
MH  - Humans
MH  - Integrin alpha3
MH  - Integrins/*genetics/metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - Peptide Mapping
EDAT- 1999/03/27 00:00
MHDA- 1999/03/27 00:01
CRDT- 1999/03/27 00:00
PHST- 1999/03/27 00:00 [pubmed]
PHST- 1999/03/27 00:01 [medline]
PHST- 1999/03/27 00:00 [entrez]
AID - S0014-5793(99)00151-9 [pii]
AID - 10.1016/s0014-5793(99)00151-9 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Feb 26;445(2-3):351-5. doi: 10.1016/s0014-5793(99)00151-9.