PMID- 10092857
OWN - NLM
STAT- MEDLINE
DCOM- 19990422
LR  - 20190620
IS  - 0014-2956 (Print)
IS  - 0014-2956 (Linking)
VI  - 259
IP  - 3
DP  - 1999 Feb
TI  - Comparisons of genomic structures and chromosomal locations of the mouse aldose
      reductase and aldose reductase-like genes.
PG  - 726-30
AB  - Aldose reductase (AR), best known as the first enzyme in the polyol pathway of
      sugar metabolism, has been implicated in a wide variety of physiological
      functions and in the etiology of diabetic complications. We have determined the
      structures and chromosomal locations of the mouse AR gene (Aldor1) and of two
      genes highly homologous to Aldor1: the fibroblast growth factor regulated protein
      gene (Fgfrp) and the androgen regulated vas deferens protein gene (Avdp). The
      number of introns and their locations in the mouse Aldor1 gene are identical to
      those of rat and human AR genes and also to those of Fgfrp and Avdp. Mouse Aldor1
      gene was found to be located near the Cald1 (Caldesmon) and Ptn (Pleiotropin)
      loci at the proximal end of chromosome 6. The closely related genes Fgfrp and
      Avdp were also mapped in this region of the chromosome, suggesting that these
      three genes may have arisen by a gene duplication event.
FAU - Ho, H T
AU  - Ho HT
AD  - Institute of Molecular Biology, University of Hong Kong, China.
FAU - Jenkins, N A
AU  - Jenkins NA
FAU - Copeland, N G
AU  - Copeland NG
FAU - Gilbert, D J
AU  - Gilbert DJ
FAU - Winkles, J A
AU  - Winkles JA
FAU - Louie, H W
AU  - Louie HW
FAU - Lee, F K
AU  - Lee FK
FAU - Chung, S S
AU  - Chung SS
FAU - Chung, S K
AU  - Chung SK
LA  - eng
SI  - GENBANK/AH007732
SI  - GENBANK/U93230
SI  - GENBANK/U93231
GR  - HL-39727/HL/NHLBI NIH HHS/United States
GR  - HL-54710/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Eur J Biochem
JT  - European journal of biochemistry
JID - 0107600
RN  - 0 (Emr4 protein, mouse)
RN  - 0 (Proteins)
RN  - 62031-54-3 (Fibroblast Growth Factors)
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - EC 1.1.1.21 (Akr1b7 protein, mouse)
RN  - EC 1.1.1.21 (Aldehyde Reductase)
SB  - IM
MH  - Aldehyde Reductase/*genetics
MH  - Animals
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - Chromosome Segregation
MH  - Diabetes Mellitus/etiology
MH  - *Epidermal Growth Factor
MH  - Fibroblast Growth Factors/genetics
MH  - Gene Duplication
MH  - Mice
MH  - Proteins/genetics
MH  - Pseudogenes/genetics
MH  - Sequence Homology, Nucleic Acid
EDAT- 1999/03/27 00:00
MHDA- 1999/03/27 00:01
CRDT- 1999/03/27 00:00
PHST- 1999/03/27 00:00 [pubmed]
PHST- 1999/03/27 00:01 [medline]
PHST- 1999/03/27 00:00 [entrez]
AID - 10.1046/j.1432-1327.1999.00110.x [doi]
PST - ppublish
SO  - Eur J Biochem. 1999 Feb;259(3):726-30. doi: 10.1046/j.1432-1327.1999.00110.x.