PMID- 10092804
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20100825
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 162
IP  - 6
DP  - 1999 Mar 15
TI  - Two constituents of the initiation complex of the mannan-binding lectin
      activation pathway of complement are encoded by a single structural gene.
PG  - 3481-90
AB  - Mannan-binding lectin (MBL) forms a multimolecular complex with at least two
      MBL-associated serine proteases, MASP-1 and MASP-2. This complex initiates the
      MBL pathway of complement activation by binding to carbohydrate structures
      present on bacteria, yeast, and viruses. MASP-1 and MASP-2 are composed of
      modular structural motifs similar to those of the C1q-associated serine proteases
      C1r and C1s. Another protein of 19 kDa with the same N-terminal sequence as the
      76-kDa MASP-2 protein is consistently detected as part of the MBL/MASP complex.
      In this study, we present the primary structure of this novel MBL-associated
      plasma protein of 19 kDa, MAp19, and demonstrate that MAp19 and MASP-2 are
      encoded by two different mRNA species generated by alternative
      splicing/polyadenylation from one structural gene.
FAU - Stover, C M
AU  - Stover CM
AD  - Department of Microbiology and Immunology, University of Leicester, United
      Kingdom.
FAU - Thiel, S
AU  - Thiel S
FAU - Thelen, M
AU  - Thelen M
FAU - Lynch, N J
AU  - Lynch NJ
FAU - Vorup-Jensen, T
AU  - Vorup-Jensen T
FAU - Jensenius, J C
AU  - Jensenius JC
FAU - Schwaeble, W J
AU  - Schwaeble WJ
LA  - eng
SI  - GENBANK/Y18281
SI  - GENBANK/Y18282
SI  - GENBANK/Y18283
SI  - GENBANK/Y18284
SI  - GENBANK/Y18285
SI  - GENBANK/Y18286
SI  - GENBANK/Y18287
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Blood Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (Collectins)
RN  - 0 (Lectins)
RN  - 0 (Mannans)
RN  - 0 (RNA, Messenger)
RN  - EC 3.4.21.- (MASP2 protein, human)
RN  - EC 3.4.21.- (Mannose-Binding Protein-Associated Serine Proteases)
RN  - EC 3.4.21.- (Serine Endopeptidases)
SB  - AIM
SB  - IM
MH  - Alternative Splicing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blood Proteins/chemistry
MH  - Carrier Proteins/chemistry/*genetics/*immunology
MH  - Collectins
MH  - Complement Activation/*genetics
MH  - Exons
MH  - Genes/*immunology
MH  - Humans
MH  - Introns
MH  - Lectins/*metabolism
MH  - Mannans/*metabolism
MH  - Mannose-Binding Protein-Associated Serine Proteases
MH  - Molecular Sequence Data
MH  - Molecular Weight
MH  - RNA, Messenger/chemistry
MH  - Rats
MH  - Sequence Analysis, DNA
MH  - Serine Endopeptidases/chemistry/*genetics/immunology
MH  - Transcription, Genetic/immunology
EDAT- 1999/03/27 00:00
MHDA- 1999/03/27 00:01
CRDT- 1999/03/27 00:00
PHST- 1999/03/27 00:00 [pubmed]
PHST- 1999/03/27 00:01 [medline]
PHST- 1999/03/27 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1999 Mar 15;162(6):3481-90.