PMID- 10092511
OWN - NLM
STAT- MEDLINE
DCOM- 19990511
LR  - 20071115
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 257
IP  - 1
DP  - 1999 Apr 2
TI  - Characterization of TFG in mus musculus and Caenorhabditis elegans.
PG  - 67-73
AB  - TFG was discovered as a fusion partner of NTRK1 in human papillary thyroid
      carcinoma. We assembled the mouse TFG cDNA from EST sequences and 5' end RACE
      product, identified full coding length TFG EST clones in pig (c17b07) and
      Schistosoma mansoni (SMNAS62), and analyzed the genomic structure of TFG in
      Caenorhabditis elegans (Y63D3A). The protein sequences of mouse, pig, and S.
      mansoni TFG are highly homologous to human TFG. The C. elegans sequence has
      diverged, but its predicted secondary structure is remarkably conserved. Human,
      mouse, and C. elegans TFG contain a putative trimeric N-terminal coiled-coil
      domain, glycosylation, myristylation, and phosphorylation sites, and SH2- and
      SH3-binding motifs. The SH2-binding motif is absent in C. elegans TFG. The
      expression of TFG does not vary among 7, 11, 15, and 19 day mouse embryonal
      stages. In situ hybridization with a TFG probe in 10, 5-day whole mouse embryos
      showed preferential staining of the limb buds, branchial arches, nasal processes,
      and brain, and weak staining of the primitive spinal cord and dorsal root
      ganglia.
CI  - Copyright 1999 Academic Press.
FAU - Mencinger, M
AU  - Mencinger M
AD  - Department of Clinical Genetics, University Hospital, Lund, S-221 85, Sweden.
      Marina.Mencinger@klingen.lu.se
FAU - Aman, P
AU  - Aman P
LA  - eng
SI  - GENBANK/U94662
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (DNA, Complementary)
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (TFG protein, human)
RN  - 0 (Tfg protein, mouse)
RN  - 0 (dnj-29 protein, C elegans)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Caenorhabditis elegans/chemistry/*genetics
MH  - *Caenorhabditis elegans Proteins
MH  - Chromosome Mapping
MH  - DNA, Complementary/genetics
MH  - Embryo, Mammalian/metabolism
MH  - Embryo, Nonmammalian
MH  - Expressed Sequence Tags
MH  - Gene Expression Regulation, Developmental
MH  - Genes, Helminth
MH  - Glycosylation
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Phosphorylation
MH  - Protein Structure, Secondary
MH  - Proteins/chemistry/*genetics
MH  - RNA, Messenger/metabolism
MH  - Schistosoma mansoni/chemistry/genetics
MH  - Sequence Homology, Amino Acid
MH  - Swine/genetics
MH  - src Homology Domains/genetics
EDAT- 1999/03/27 00:00
MHDA- 1999/03/27 00:01
CRDT- 1999/03/27 00:00
PHST- 1999/03/27 00:00 [pubmed]
PHST- 1999/03/27 00:01 [medline]
PHST- 1999/03/27 00:00 [entrez]
AID - S0006-291X(99)90417-5 [pii]
AID - 10.1006/bbrc.1999.0417 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 Apr 2;257(1):67-73. doi: 10.1006/bbrc.1999.0417.