PMID- 10090727
OWN - NLM
STAT- MEDLINE
DCOM- 19990415
LR  - 20190516
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 13
IP  - 6
DP  - 1999 Mar 15
TI  - Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice.
PG  - 709-17
AB  - Members of the LEF-1/TCF family of transcription factors have been implicated in 
      the transduction of Wnt signals. However, targeted gene inactivations of Lef1,
      Tcf1, or Tcf4 in the mouse do not produce phenotypes that mimic any known Wnt
      mutation. Here we show that null mutations in both Lef1 and Tcf1, which are
      expressed in an overlapping pattern in the early mouse embryo, cause a severe
      defect in the differentiation of paraxial mesoderm and lead to the formation of
      additional neural tubes, phenotypes identical to those reported for
      Wnt3a-deficient mice. In addition, Lef1(-/-)Tcf1(-/-) embryos have defects in the
      formation of the placenta and in the development of limb buds, which fail both to
      express Fgf8 and to form an apical ectodermal ridge. Together, these data provide
      evidence for a redundant role of LEF-1 and TCF-1 in Wnt signaling during mouse
      development.
FAU - Galceran, J
AU  - Galceran J
AD  - Howard Hughes Medical Institute and Departments of Microbiology and Biochemistry,
      University of California, San Francisco, California 94143, USA.
FAU - Farinas, I
AU  - Farinas I
FAU - Depew, M J
AU  - Depew MJ
FAU - Clevers, H
AU  - Clevers H
FAU - Grosschedl, R
AU  - Grosschedl R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (DNA Primers)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Hepatocyte Nuclear Factor 1-alpha)
RN  - 0 (Hnf1a protein, mouse)
RN  - 0 (Lef1 protein, mouse)
RN  - 0 (Lymphoid Enhancer-Binding Factor 1)
RN  - 0 (Proteins)
RN  - 0 (T Cell Transcription Factor 1)
RN  - 0 (Transcription Factors)
RN  - 0 (Wnt Proteins)
RN  - 0 (Wnt3 Protein)
RN  - 0 (Wnt3A Protein)
RN  - 0 (Wnt3a protein, mouse)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - DNA Primers
MH  - DNA-Binding Proteins/*genetics
MH  - Embryo, Mammalian/ultrastructure
MH  - Hepatocyte Nuclear Factor 1-alpha
MH  - Limb Deformities, Congenital/*genetics
MH  - Lymphoid Enhancer-Binding Factor 1
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Microscopy, Electron, Scanning
MH  - Phenotype
MH  - Proteins/*genetics
MH  - T Cell Transcription Factor 1
MH  - Transcription Factors/*genetics
MH  - Wnt Proteins
MH  - Wnt3 Protein
MH  - Wnt3A Protein
PMC - PMC316557
EDAT- 1999/03/25 00:00
MHDA- 1999/03/25 00:01
CRDT- 1999/03/25 00:00
PHST- 1999/03/25 00:00 [pubmed]
PHST- 1999/03/25 00:01 [medline]
PHST- 1999/03/25 00:00 [entrez]
AID - 10.1101/gad.13.6.709 [doi]
PST - ppublish
SO  - Genes Dev. 1999 Mar 15;13(6):709-17. doi: 10.1101/gad.13.6.709.