PMID- 10087612
OWN - NLM
STAT- MEDLINE
DCOM- 19990527
LR  - 20191024
IS  - 0962-8924 (Print)
IS  - 0962-8924 (Linking)
VI  - 9
IP  - 1
DP  - 1999 Jan
TI  - Waltzing with WASP.
PG  - 15-9
AB  - Wiskott-Aldrich syndrome (WAS) is an inherited immune deficiency that is marked
      by eczema, bleeding and recurrent infections. The lymphocytes and platelets of
      WAS patients display cytoskeletal abnormalities, and their T lymphocytes show a
      diminished proliferative response to stimulation through the T-cell receptor-CD3 
      complex (TCR-CD3). The product of the WAS gene, WAS protein (WASP), binds to the 
      small GTPase Cdc42. Small GTPases of the Rho family are crucial for the
      regulation of the actin-based cytoskeleton. WASP and its relative NWASP might
      play an important role in regulating the actin cytoskeleton. Since both WASP and 
      NWASP have the potential to bind to multiple proteins, they might serve as a hub 
      to coordinate the redistribution of many cellular signals to the actin
      cytoskeleton. In this review, the authors discuss the possible role of WASP/NWASP
      and of the newly described protein WIP, which interacts with WASP and NWASP, in
      coupling signals from the T-cell receptor to the actin-based cytoskeleton.
FAU - Ramesh, N
AU  - Ramesh N
AD  - Dept of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
      rameshvn@a1.tch.harvard.edu
FAU - Anton, I M
AU  - Anton IM
FAU - Martinez-Quiles, N
AU  - Martinez-Quiles N
FAU - Geha, R S
AU  - Geha RS
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Trends Cell Biol
JT  - Trends in cell biology
JID - 9200566
RN  - 0 (Actins)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Proteins)
RN  - 0 (Receptor-CD3 Complex, Antigen, T-Cell)
RN  - 0 (WAS protein, human)
RN  - 0 (WIPF1 protein, human)
RN  - 0 (Wiskott-Aldrich Syndrome Protein)
RN  - EC 3.6.1.- (GTP Phosphohydrolases)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
RN  - EC 3.6.5.2 (rho GTP-Binding Proteins)
SB  - IM
CIN - Trends Cell Biol. 1999 Jun;9(6):211-2. PMID: 10354565
MH  - Actins
MH  - Animals
MH  - Carrier Proteins/metabolism
MH  - Cytoskeletal Proteins
MH  - Cytoskeleton
MH  - GTP Phosphohydrolases/metabolism
MH  - GTP-Binding Proteins/metabolism
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins
MH  - Lymphocytes
MH  - Proteins/*metabolism
MH  - Receptor-CD3 Complex, Antigen, T-Cell/metabolism
MH  - Signal Transduction
MH  - Wiskott-Aldrich Syndrome/*metabolism
MH  - Wiskott-Aldrich Syndrome Protein
MH  - rho GTP-Binding Proteins
RF  - 58
EDAT- 1999/03/24 00:00
MHDA- 1999/03/24 00:01
CRDT- 1999/03/24 00:00
PHST- 1999/03/24 00:00 [pubmed]
PHST- 1999/03/24 00:01 [medline]
PHST- 1999/03/24 00:00 [entrez]
AID - S0962-8924(98)01411-1 [pii]
AID - 10.1016/s0962-8924(98)01411-1 [doi]
PST - ppublish
SO  - Trends Cell Biol. 1999 Jan;9(1):15-9. doi: 10.1016/s0962-8924(98)01411-1.