PMID- 10087299
OWN - NLM
STAT- MEDLINE
DCOM- 19990513
LR  - 20190905
IS  - 0938-8990 (Print)
IS  - 0938-8990 (Linking)
VI  - 10
IP  - 4
DP  - 1999 Apr
TI  - Exon structure of the nuclear factor I DNA-binding domain from C. elegans to
      mammals.
PG  - 390-6
AB  - The Nuclear Factor I (NFI) family of DNA-binding proteins is essential for
      adenovirus DNA replication and the transcription of many cellular genes. Mammals 
      have four genes encoding NFI proteins, C. elegans has only a single NFI gene, and
      prokaryotes have none. To assess the relationship between members of this
      unusually small family of transcription/replication factors, we mapped the
      chromosomal locations of the four murine NFI genes and analyzed the exons
      encoding the DNA-binding domains of the mouse, Amphioxus, and C. elegans NFI
      genes. The four murine NFI genes are on Chrs 4 (Nfia and Nfib), 8 (Nfix), and 10 
      (Nfic), suggesting early duplication of the genes and dispersal throughout the
      genome. The DNA-binding domains of all four NFI genes are encoded by large (532
      bp) exons with identical splice acceptor and donor sites in each. In contrast,
      the C. elegans nfi-1 gene has four phased introns interrupting this DNA-binding, 
      domain-encoding exon, and the last exon extends 213 bp past the splice site used 
      in all four murine genes. In addition, the introns present in C. elegans nfi-1
      are missing from the NFI genes of Amphioxus and all mammalian genomes examined.
      This analysis of the exon structure of the C. elegans and murine NFI genes
      indicates that the murine genes were probably generated by duplication of a C.
      elegans-like ancestral gene, but that significant changes have occurred in the
      genomic organization of either the C. elegans or murine NFI genes during
      evolution.
FAU - Fletcher, C F
AU  - Fletcher CF
AD  - Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer
      Research and Development Center, Frederick, Maryland 21702, USA.
FAU - Jenkins, N A
AU  - Jenkins NA
FAU - Copeland, N G
AU  - Copeland NG
FAU - Chaudhry, A Z
AU  - Chaudhry AZ
FAU - Gronostajski, R M
AU  - Gronostajski RM
LA  - eng
SI  - GENBANK/AF059517
SI  - GENBANK/AF059518
SI  - GENBANK/AF059519
SI  - GENBANK/AF059520
SI  - GENBANK/AF059521
SI  - GENBANK/AF111263
SI  - GENBANK/AF111264
SI  - GENBANK/AF111265
SI  - GENBANK/AF111266
GR  - HD34908/HD/NICHD NIH HHS/United States
GR  - N01-CO-74101/CO/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mamm Genome
JT  - Mammalian genome : official journal of the International Mammalian Genome Society
JID - 9100916
RN  - 0 (CCAAT-Enhancer-Binding Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (NFI Transcription Factors)
RN  - 0 (NFIA protein, human)
RN  - 0 (Nfia protein, mouse)
RN  - 0 (Nfic protein, mouse)
RN  - 0 (Nfix protein, mouse)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (Y-Box-Binding Protein 1)
RN  - 0 (YBX1 protein, human)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Binding Sites/genetics
MH  - *CCAAT-Enhancer-Binding Proteins
MH  - Caenorhabditis elegans/genetics
MH  - DNA/genetics
MH  - DNA-Binding Proteins/*genetics
MH  - Evolution, Molecular
MH  - Exons/*genetics
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - NFI Transcription Factors
MH  - Nuclear Proteins
MH  - Transcription Factors/genetics
MH  - Y-Box-Binding Protein 1
EDAT- 1999/03/24 00:00
MHDA- 1999/03/24 00:01
CRDT- 1999/03/24 00:00
PHST- 1999/03/24 00:00 [pubmed]
PHST- 1999/03/24 00:01 [medline]
PHST- 1999/03/24 00:00 [entrez]
AID - 10.1007/s003359901008 [doi]
PST - ppublish
SO  - Mamm Genome. 1999 Apr;10(4):390-6. doi: 10.1007/s003359901008.