PMID- 10087294
OWN - NLM
STAT- MEDLINE
DCOM- 19990513
LR  - 20190905
IS  - 0938-8990 (Print)
IS  - 0938-8990 (Linking)
VI  - 10
IP  - 4
DP  - 1999 Apr
TI  - Rat osteotesticular phosphatase gene (Esp): genomic structure and chromosome
      location.
PG  - 366-70
AB  - Osteotesticular phosphatase (OST-PTPase) is a class III receptor-type tyrosine
      phosphatase (RPTPase). It has 10 tandem fibronectin III-like (FN-III) repeats in 
      the extracellular region and two phosphatase domains in the intracellular region.
      The expression of the rat OST-PTPase gene, Esp, is restricted to osteoblasts and 
      Sertoli cells, and the transcript level in osteoblasts is highly up-regulated by 
      parathyroid hormone and cAMP treatment. We report here the cloning and
      characterization of the rat Esp gene, including a 2.9-kb 5' flanking region
      sequence. Two potential binding sites for Osf2/Cbfa1, an osteoblast-specific
      transcription factor, are present in the promoter. Esp is composed of 35 exons,
      but spans merely 20 kb, making it the most compact RPTPase gene identified. Each 
      FN-III repeat is encoded by a single exon flanked with phase 1 introns. Two
      phosphatase domains are encoded by 16 exons in a genomic organization similar to 
      those in RPRPalpha, RPTPgamma, and Ptprc genes. Esp was mapped by fluorescence in
      situ hybridization to rat chromosome 13q1. These results represent the first
      genomic structure of a mammalian class III RPTPase gene.
FAU - Lathrop, W
AU  - Lathrop W
AD  - Bayer Research Center, Pharmaceutical Division, Bayer Corporation, 400 Morgan
      Lane, West Haven, Connecticut 06516-4175, USA.
FAU - Jordan, J
AU  - Jordan J
FAU - Eustice, D
AU  - Eustice D
FAU - Chen, D
AU  - Chen D
LA  - eng
SI  - GENBANK/AF079319
PT  - Journal Article
PL  - United States
TA  - Mamm Genome
JT  - Mammalian genome : official journal of the International Mammalian Genome Society
JID - 9100916
RN  - 0 (Receptors, Cell Surface)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatases)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - *Genome
MH  - Male
MH  - Molecular Sequence Data
MH  - Osteoblasts/enzymology
MH  - Promoter Regions, Genetic/genetics
MH  - Protein Tyrosine Phosphatases/*genetics
MH  - Rats
MH  - Receptors, Cell Surface/*genetics
MH  - Sequence Analysis, DNA
MH  - Testis/enzymology
EDAT- 1999/03/24 00:00
MHDA- 1999/03/24 00:01
CRDT- 1999/03/24 00:00
PHST- 1999/03/24 00:00 [pubmed]
PHST- 1999/03/24 00:01 [medline]
PHST- 1999/03/24 00:00 [entrez]
AID - 10.1007/s003359901003 [doi]
PST - ppublish
SO  - Mamm Genome. 1999 Apr;10(4):366-70. doi: 10.1007/s003359901003.