PMID- 10087292
OWN - NLM
STAT- MEDLINE
DCOM- 19990513
LR  - 20190905
IS  - 0938-8990 (Print)
IS  - 0938-8990 (Linking)
VI  - 10
IP  - 4
DP  - 1999 Apr
TI  - RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal
      positions.
PG  - 358-61
AB  - We recently reported the molecular cloning of a novel transforming rat brain
      cDNA, rbc7, that encodes a Ras activator (Ebinu et al. Science 280, p. 1082,
      1998). We proposed that this cDNA is a 5' and 3' truncated version of a larger
      normal transcript that encodes a predicted 90-kDa protein which we called RasGRP 
      (Ras guanyl nucleotide releasing protein). We have now studied the structure of
      the mouse and human sequences and confirmed our conclusions about the nature of
      the 5' truncation. The human gene has been localized to 15q15 by an in situ
      hybridization technique, while the mouse gene has been positioned on Chr 2 near
      thrombospondin by linkage analysis. The relatedness of RasGRP to another human
      sequence and a hypothetical nematode protein are also discussed.
FAU - Bottorff, D
AU  - Bottorff D
AD  - Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada, T6G
      2H7.
FAU - Ebinu, J
AU  - Ebinu J
FAU - Stone, J C
AU  - Stone JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mamm Genome
JT  - Mammalian genome : official journal of the International Mammalian Genome Society
JID - 9100916
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Guanine Nucleotide Exchange Factors)
RN  - 0 (RASGRP1 protein, human)
RN  - 0 (Rasgrp1 protein, mouse)
RN  - 0 (Rasgrp1 protein, rat)
RN  - EC 3.6.5.2 (ras Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 15
MH  - DNA, Complementary/analysis/*genetics
MH  - DNA-Binding Proteins/*genetics
MH  - *Guanine Nucleotide Exchange Factors
MH  - Humans
MH  - In Situ Hybridization
MH  - Mice
MH  - Molecular Sequence Data
MH  - Rats
MH  - Sequence Alignment
MH  - ras Proteins/genetics
EDAT- 1999/03/24 00:00
MHDA- 1999/03/24 00:01
CRDT- 1999/03/24 00:00
PHST- 1999/03/24 00:00 [pubmed]
PHST- 1999/03/24 00:01 [medline]
PHST- 1999/03/24 00:00 [entrez]
AID - 10.1007/s003359901001 [doi]
PST - ppublish
SO  - Mamm Genome. 1999 Apr;10(4):358-61. doi: 10.1007/s003359901001.