PMID- 10087289
OWN - NLM
STAT- MEDLINE
DCOM- 19990513
LR  - 20190905
IS  - 0938-8990 (Print)
IS  - 0938-8990 (Linking)
VI  - 10
IP  - 4
DP  - 1999 Apr
TI  - Genotyping new BXD recombinant inbred mouse strains and comparison of BXD and
      consensus maps.
PG  - 335-48
AB  - Nine additional BXD recombinant inbred (RI) strains have been developed from the 
      F2 cross of C57BL/6J and DBA/2J mouse strains. A tenth line stopped breeding in
      the F12 generation. F20 generation breeding pairs from the nine surviving strains
      and an F12 pair from the extinct line were genotyped at 319 genetic markers
      (primarily microsatellites) spanning most of the genome. Where typing data were
      lacking, the established set of 26 BXD strains also were genotyped at these same 
      loci. The availability of these additional nine strains enhances the value of the
      BXD RI set for analysis of complex phenotypic traits. The proportion of loci
      still segregating at the F20 generation was found to closely approximate
      expectation, suggesting that selection favoring the retention of heterozygosity
      is not a strong factor. However, the number of crossovers between adjacent
      markers was frequently less than predicted from consensus map distances. A
      significant deficiency of recombinants was observed on Chrs 3, 4, 14, and X. On
      Chr 14, the estimated cumulative BXD map distance between the most proximal and
      distal markers was only 30.2 cM, compared with a distance of 60.0 cM in the
      consensus map. On the X Chr, the estimated and predicted cumulative distances
      were 38.8 and 69.5 cM, respectively. Over all chromosomes, the BXD RI map is
      14.5% shorter than predicted from the consensus map. It is suggested that
      distances in some of the consensus maps are inflated. Alternatively, recombinant 
      genotypes could be selected against during inbreeding owing to allelic
      interactions affecting fitness. The latter interpretation implies that relatively
      strong intrachromosomal epistasis is common.
FAU - Taylor, B A
AU  - Taylor BA
AD  - The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA.
FAU - Wnek, C
AU  - Wnek C
FAU - Kotlus, B S
AU  - Kotlus BS
FAU - Roemer, N
AU  - Roemer N
FAU - MacTaggart, T
AU  - MacTaggart T
FAU - Phillips, S J
AU  - Phillips SJ
LA  - eng
GR  - CA344196/CA/NCI NIH HHS/United States
GR  - GM18684/GM/NIGMS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mamm Genome
JT  - Mammalian genome : official journal of the International Mammalian Genome Society
JID - 9100916
SB  - IM
MH  - Animals
MH  - Chromosome Mapping
MH  - Female
MH  - Genotype
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred DBA
MH  - Mice, Inbred Strains/*genetics
MH  - *Recombination, Genetic
EDAT- 1999/03/24 00:00
MHDA- 1999/03/24 00:01
CRDT- 1999/03/24 00:00
PHST- 1999/03/24 00:00 [pubmed]
PHST- 1999/03/24 00:01 [medline]
PHST- 1999/03/24 00:00 [entrez]
AID - 10.1007/s003359900998 [doi]
PST - ppublish
SO  - Mamm Genome. 1999 Apr;10(4):335-48. doi: 10.1007/s003359900998.