PMID- 10087198
OWN - NLM
STAT- MEDLINE
DCOM- 19990524
LR  - 20171116
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 56
IP  - 3
DP  - 1999 Mar 15
TI  - Coding sequence, genomic organization, chromosomal localization, and expression
      pattern of the signalosome component Cops2: the mouse homologue of Drosophila
      alien.
PG  - 310-6
AB  - The Drosophila alien gene is highly homologous to the human thyroid receptor
      interacting protein, TRIP15/COPS2, which is a component of the recently
      identified signalosome protein complex. We identified the mouse homologue of
      Drosophila alien through homology searches of the EST database. We found that the
      mouse cDNA encodes a predicted 443-amino-acid protein, which migrates at
      approximately 50 kDa. The gene for the mouse alien homologue, named Cops2,
      includes 12 coding exons spanning approximately 30 kb of genomic DNA on the
      central portion of mouse chromosome 2. Mouse Cops2 is widely expressed in
      embryonic, fetal, and adult tissues beginning as early as E7.5. Mouse Cops2 cDNA 
      hybridizes to two mRNA bands in all tissues at approximately 2.3 and
      approximately 4 kb, with an additional approximately 1.9-kb band in liver.
      Immunostaining of native and epitope tagged proteins localized the mouse Cops2
      protein in both the cytoplasm and the nucleus, with larger amounts in the nucleus
      in some cells.
CI  - Copyright 1999 Academic Press.
FAU - Schaefer, L
AU  - Schaefer L
AD  - Myogenesis Research Laboratory, Massachusetts General Hospital, 149 13th Street, 
      Charlestown, Massachusetts 02129, USA.
FAU - Beermann, M L
AU  - Beermann ML
FAU - Miller, J B
AU  - Miller JB
LA  - eng
SI  - GENBANK/AF087688
SI  - GENBANK/AF114236
SI  - GENBANK/AF114237
SI  - GENBANK/AF114238
SI  - GENBANK/AF114239
SI  - GENBANK/AF114240
SI  - GENBANK/AF114241
SI  - GENBANK/AF114242
SI  - GENBANK/AF114244
SI  - GENBANK/AF114245
SI  - GENBANK/AF114246
SI  - GENBANK/AF114247
SI  - GENBANK/AH007585
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Alien protein, Drosophila)
RN  - 0 (COPS2 protein, human)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cops2 protein, mouse)
RN  - 0 (Insect Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Proteins)
RN  - 0 (Receptors, Thyroid Hormone)
RN  - 0 (Repressor Proteins)
RN  - 0 (Transcription Factors)
RN  - EC 3.4.19.12 (COP9 Signalosome Complex)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Blotting, Northern
MH  - COP9 Signalosome Complex
MH  - Carrier Proteins/*genetics/*metabolism
MH  - Cells, Cultured/cytology
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - Crosses, Genetic
MH  - Exons
MH  - Expressed Sequence Tags
MH  - Female
MH  - Humans
MH  - Immunoblotting
MH  - Immunohistochemistry
MH  - Insect Proteins/genetics
MH  - Introns
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Models, Genetic
MH  - Molecular Sequence Data
MH  - *Nuclear Proteins
MH  - *Proteins
MH  - *Receptors, Thyroid Hormone
MH  - Repressor Proteins
MH  - Sequence Homology, Amino Acid
MH  - *Signal Transduction
MH  - Tissue Distribution
MH  - *Transcription Factors
EDAT- 1999/03/24 00:00
MHDA- 1999/03/24 00:01
CRDT- 1999/03/24 00:00
PHST- 1999/03/24 00:00 [pubmed]
PHST- 1999/03/24 00:01 [medline]
PHST- 1999/03/24 00:00 [entrez]
AID - S0888-7543(98)95728-7 [pii]
AID - 10.1006/geno.1998.5728 [doi]
PST - ppublish
SO  - Genomics. 1999 Mar 15;56(3):310-6. doi: 10.1006/geno.1998.5728.