PMID- 10086727
OWN - NLM
STAT- MEDLINE
DCOM- 19990407
LR  - 20190915
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 13
IP  - 3
DP  - 1999 Mar
TI  - Identification of a novel molecular partner of the E2A gene in childhood
      leukemia.
PG  - 369-75
AB  - The 'promiscuous' E2A gene, at 19p13.3, is fused with two different molecular
      partners, PBX1 and HLF, following two chromosome translocations recurrent in
      childhood pre-B ALL. We have identified a novel gene, FB1, by virtue of its
      fusion with E2A and by a combination of molecular techniques. FB1 was localized
      on 19q13.4, suggesting that the novel chimera originated by a cryptic
      rearrangement of chromosome 19. Two FB1 transcripts, of 1.2 kb and 1.1 kb, are
      differentially expressed at low level in a variety of human tissues, including
      hemopoietic cell lines from different lineages. Accordingly, FB1 cDNA displays
      high homology with a number of cDNA clones from different human tissues. High
      homology was found also with cDNA clones from mouse and rat, suggesting that the 
      sequence might be conserved at least among mammals. The function of the putative 
      FB1 protein, however, is currently unknown as database sequence comparisons have 
      failed to reveal strong homology with known proteins. The E2A/FB1 fusion appears 
      to be a recurrent feature of pre-B ALLs, suggesting that it might have a role in 
      the development and/or progression of leukemogenesis.
FAU - Brambillasca, F
AU  - Brambillasca F
AD  - Dipartimento di Genetica e di Biologia dei Microrganismi, Universita di Milano,
      Italy.
FAU - Mosna, G
AU  - Mosna G
FAU - Colombo, M
AU  - Colombo M
FAU - Rivolta, A
AU  - Rivolta A
FAU - Caslini, C
AU  - Caslini C
FAU - Minuzzo, M
AU  - Minuzzo M
FAU - Giudici, G
AU  - Giudici G
FAU - Mizzi, L
AU  - Mizzi L
FAU - Biondi, A
AU  - Biondi A
FAU - Privitera, E
AU  - Privitera E
LA  - eng
SI  - GENBANK/AF052052
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (Adenovirus E2 Proteins)
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (TFPT protein, human)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adenovirus E2 Proteins/*genetics
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Basic Helix-Loop-Helix Transcription Factors
MH  - Child
MH  - Chromosome Mapping
MH  - Chromosomes, Artificial, Yeast
MH  - Chromosomes, Human, Pair 19
MH  - Cloning, Molecular
MH  - DNA, Complementary
MH  - DNA-Binding Proteins/*genetics
MH  - Humans
MH  - Molecular Sequence Data
MH  - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - RNA, Messenger/genetics
MH  - *Transcription Factors
EDAT- 1999/03/23 00:00
MHDA- 1999/03/23 00:01
CRDT- 1999/03/23 00:00
PHST- 1999/03/23 00:00 [pubmed]
PHST- 1999/03/23 00:01 [medline]
PHST- 1999/03/23 00:00 [entrez]
AID - 10.1038/sj.leu.2401338 [doi]
PST - ppublish
SO  - Leukemia. 1999 Mar;13(3):369-75. doi: 10.1038/sj.leu.2401338.