PMID- 10086381
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20110425
IS  - 1078-8956 (Print)
IS  - 1078-8956 (Linking)
VI  - 5
IP  - 3
DP  - 1999 Mar
TI  - Modulation of oncogenic potential by alternative gene use in human prostate
      cancer.
PG  - 275-9
AB  - Only a small percentage of primary prostate cancers have genetic changes. In
      contrast, nearly 90% of clinically significant human prostate cancers seems to
      express high levels of the nuclear phosphoprotein pp32 by in situ hybridization. 
      Because pp32 inhibits oncogene-mediated transformation, we investigated its
      paradoxical expression in cancer by comparing the sequence and function of pp32
      species from paired benign prostate tissue and adjacent prostatic carcinoma from 
      three patients. Here we demonstrate that pp32 is expressed in benign prostatic
      tissue, but pp32r1 and pp32r2, closely-related genes located on different
      chromosomes, are expressed in prostate cancer. Although pp32 is a tumor
      suppressor, pp32r1 and pp32r2 are tumorigenic. Alternative use of the pp32,
      pp32r1 and pp32r2 genes may modulate the oncogenic potential of human prostate
      cancer.
FAU - Kadkol, S S
AU  - Kadkol SS
AD  - Department of Pathology, The Johns Hopkins University School of Medicine,
      Baltimore, Maryland 21205, USA.
FAU - Brody, J R
AU  - Brody JR
FAU - Pevsner, J
AU  - Pevsner J
FAU - Bai, J
AU  - Bai J
FAU - Pasternack, G R
AU  - Pasternack GR
LA  - eng
GR  - R01 CA 54404/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Nat Med
JT  - Nature medicine
JID - 9502015
RN  - 0 (Nuclear Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (RNA, Messenger)
SB  - IM
CIN - Nat Med. 1999 Mar;5(3):264-5. PMID: 10086374
EIN - Nat Med 1999 Sep;5(9):1087
MH  - *Alternative Splicing
MH  - Humans
MH  - Male
MH  - Nuclear Proteins/*genetics
MH  - Phosphoproteins/genetics
MH  - Prostatic Hyperplasia/*genetics
MH  - Prostatic Neoplasms/*genetics
MH  - RNA, Messenger
EDAT- 1999/03/23 03:03
MHDA- 2001/03/23 10:01
CRDT- 1999/03/23 03:03
PHST- 1999/03/23 03:03 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1999/03/23 03:03 [entrez]
AID - 10.1038/6488 [doi]
PST - ppublish
SO  - Nat Med. 1999 Mar;5(3):275-9. doi: 10.1038/6488.