PMID- 10086356
OWN - NLM
STAT- MEDLINE
DCOM- 19990329
LR  - 20191210
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 398
IP  - 6723
DP  - 1999 Mar 11
TI  - The mouse mahogany locus encodes a transmembrane form of human attractin.
PG  - 152-6
AB  - Agouti protein and agouti-related protein are homologous paracrine signalling
      molecules that normally regulate hair colour and body weight, respectively, by
      antagonizing signalling through melanocortin receptors. Expression of Agouti is
      normally limited to the skin, but rare alleles from which Agouti is expressed
      ubiquitously, such as lethal yellow, have pleiotropic effects that include a
      yellow coat, obesity, increased linear growth, and immune defects. The mahogany
      (mg) mutation suppresses the effects of lethal yellow on pigmentation and body
      weight, and results of our previous genetic studies place mg downstream of
      transcription of Agouti but upstream of melanocortin receptors. Here we use
      positional cloning to identify a candidate gene for mahogany, Mgca. The predicted
      protein encoded by Mgca is a 1,428-amino-acid, single-transmembrane-domain
      protein that is expressed in many tissues, including pigment cells and the
      hypothalamus. The extracellular domain of the Mgca protein is the orthologue of
      human attractin, a circulating molecule produced by activated T cells that has
      been implicated in immune-cell interactions. These observations provide new
      insight into the regulation of energy metabolism and indicate a molecular basis
      for crosstalk between melanocortin-receptor signalling and immune function.
FAU - Gunn, T M
AU  - Gunn TM
AD  - Department of Pediatrics, Howard Hughes Medical Institute, Stanford University
      School of Medicine, California 94305-5428, USA.
FAU - Miller, K A
AU  - Miller KA
FAU - He, L
AU  - He L
FAU - Hyman, R W
AU  - Hyman RW
FAU - Davis, R W
AU  - Davis RW
FAU - Azarani, A
AU  - Azarani A
FAU - Schlossman, S F
AU  - Schlossman SF
FAU - Duke-Cohan, J S
AU  - Duke-Cohan JS
FAU - Barsh, G S
AU  - Barsh GS
LA  - eng
SI  - GENBANK/AF119821
SI  - GENBANK/AF120317
SI  - GENBANK/AF120318
SI  - GENBANK/AF155960
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (AGRP protein, human)
RN  - 0 (ASIP protein, human)
RN  - 0 (ATRN protein, human)
RN  - 0 (Agouti Signaling Protein)
RN  - 0 (Agouti-Related Protein)
RN  - 0 (Agrp protein, mouse)
RN  - 0 (Atrn protein, mouse)
RN  - 0 (Glycoproteins)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Proteins)
RN  - 0 (a protein, mouse)
RN  - 62229-50-9 (Epidermal Growth Factor)
SB  - IM
MH  - Agouti Signaling Protein
MH  - Agouti-Related Protein
MH  - Amino Acid Sequence
MH  - Animals
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - Crosses, Genetic
MH  - Epidermal Growth Factor/chemistry
MH  - Glycoproteins/chemistry/*genetics/physiology
MH  - Humans
MH  - *Intercellular Signaling Peptides and Proteins
MH  - Membrane Proteins/chemistry/*genetics/physiology
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Proteins/metabolism
MH  - Sequence Homology, Amino Acid
EDAT- 1999/03/23 03:03
MHDA- 2001/03/23 10:01
CRDT- 1999/03/23 03:03
PHST- 1999/03/23 03:03 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1999/03/23 03:03 [entrez]
AID - 10.1038/18217 [doi]
PST - ppublish
SO  - Nature. 1999 Mar 11;398(6723):152-6. doi: 10.1038/18217.