PMID- 10086341
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20161124
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 18
IP  - 10
DP  - 1999 Mar 11
TI  - Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein
      expressed in proliferating cells.
PG  - 1867-79
AB  - Shc adaptor proteins play a role in linking activated cell surface receptors to
      the Ras signaling pathway in response to receptor mediated tyrosine kinase
      activation. While the function of Shc in the activation of the Ras pathway via
      binding to Grb2 has been well characterized, it is becoming increasingly apparent
      that Shc participates in additional signaling pathways through interactions with 
      other cytoplasmic proteins. Using the yeast two-hybrid system, we have identified
      a unique Shc binding protein designated PAL (Protein expressed in Activated
      Lymphocytes) with no similarity to other known proteins. mPAL binds specifically 
      to the Shc SH2 domain and unlike previously described Shc SH2 domain-protein
      interactions, the association of mPAL and Shc is phosphotyrosine-independent.
      Both mPAL RNA and protein expression are restricted to tissues containing
      actively dividing cells and proliferating cells in culture. mPAL expression is
      induced upon growth factor stimulation and is down-regulated upon growth
      inhibition. This pattern, and timing of mPAL expression and its association with 
      the Shc adaptor molecule suggests a role for this protein in signaling pathways
      governing cell cycle progression.
FAU - Schmandt, R
AU  - Schmandt R
AD  - Ontario Cancer Institute, University of Toronto, Canada.
FAU - Liu, S K
AU  - Liu SK
FAU - McGlade, C J
AU  - McGlade CJ
LA  - eng
SI  - GENBANK/AF017152
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Adaptor Proteins, Vesicular Transport)
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA, Complementary)
RN  - 0 (Proteins)
RN  - 0 (SHC1 protein, human)
RN  - 0 (Shc Signaling Adaptor Proteins)
RN  - 0 (Shc1 protein, mouse)
RN  - 0 (Shcbp1 protein, mouse)
RN  - 0 (Src Homology 2 Domain-Containing, Transforming Protein 1)
SB  - IM
MH  - 3T3 Cells
MH  - *Adaptor Proteins, Signal Transducing
MH  - *Adaptor Proteins, Vesicular Transport
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Carrier Proteins/genetics/*metabolism
MH  - Cell Division
MH  - Cloning, Molecular
MH  - DNA, Complementary
MH  - Down-Regulation
MH  - Humans
MH  - Lymphocyte Activation
MH  - Mice
MH  - Molecular Sequence Data
MH  - Phosphorylation
MH  - Proteins/*metabolism
MH  - Rabbits
MH  - Shc Signaling Adaptor Proteins
MH  - Src Homology 2 Domain-Containing, Transforming Protein 1
MH  - T-Lymphocytes
MH  - Yeasts
MH  - *src Homology Domains
EDAT- 1999/03/23 00:00
MHDA- 1999/03/23 00:01
CRDT- 1999/03/23 00:00
PHST- 1999/03/23 00:00 [pubmed]
PHST- 1999/03/23 00:01 [medline]
PHST- 1999/03/23 00:00 [entrez]
AID - 10.1038/sj.onc.1202507 [doi]
PST - ppublish
SO  - Oncogene. 1999 Mar 11;18(10):1867-79. doi: 10.1038/sj.onc.1202507.