PMID- 10085077
OWN - NLM
STAT- MEDLINE
DCOM- 19990429
LR  - 20190508
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 13
DP  - 1999 Mar 26
TI  - TWEAK induces angiogenesis and proliferation of endothelial cells.
PG  - 8455-9
AB  - TWEAK is a recently described member of the Tumor Necrosis Factor (TNF) ligand
      family whose transcripts are present in a wide variety of human tissues
      (Chicheportiche, Y., Bourdon, P. R., Xu, H., Hsu Y. M., Scott, H., Hession, C.,
      Garcia, I., and Browning, J. L. (1997) J. Biol. Chem. 272, 32401-32410). TWEAK is
      a weak inducer of apoptosis in transformed cells when administered with
      interferon-gamma or cycloheximide (Chicheportiche, Y., Bourdon, P. R., Xu, H.,
      Hsu Y. M., Scott, H., Hession, C., Garcia, I., and Browning, J. L. (1997) J.
      Biol. Chem. 272, 32401-32410; Masters, S. A., Sheridan, J. P., Pitti, R. M.,
      Brush, A. G., and Ashkenazi, A. (1998) Curr. Biol. 8, 525-528) and also promotes 
      IL-8 secretion in cultured cells. We report here that picomolar concentrations of
      recombinant soluble TWEAK induce proliferation in a variety of normal human
      endothelial cells and in aortic smooth muscle cells and reduce culture
      requirements for serum and growth factors. Blocking antibodies to Vascular
      Endothelial Growth Factor (VEGF) do not significantly inhibit TWEAK-induced
      proliferation, indicating that TWEAK does not function indirectly through
      up-regulation of VEGF. Pellets containing TWEAK induce a strong angiogenic
      response when implanted in rat corneas, suggesting a role for TWEAK in
      vasculature formation in vivo.
FAU - Lynch, C N
AU  - Lynch CN
AD  - Abbott Laboratories, Abbott Park, Illinois 60064, USA.
FAU - Wang, Y C
AU  - Wang YC
FAU - Lund, J K
AU  - Lund JK
FAU - Chen, Y W
AU  - Chen YW
FAU - Leal, J A
AU  - Leal JA
FAU - Wiley, S R
AU  - Wiley SR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cytokine TWEAK)
RN  - 0 (Cytokines)
RN  - 0 (Endothelial Growth Factors)
RN  - 0 (Lymphokines)
RN  - 0 (RNA, Messenger)
RN  - 0 (TNFSF12 protein, human)
RN  - 0 (Tumor Necrosis Factors)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Vascular Endothelial Growth Factors)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
SB  - IM
MH  - Animals
MH  - Apoptosis Regulatory Proteins
MH  - Carrier Proteins/*pharmacology
MH  - Cell Division/genetics
MH  - Cells, Cultured
MH  - Cornea/*blood supply
MH  - Cytokine TWEAK
MH  - Cytokines/metabolism
MH  - Endothelial Growth Factors/metabolism
MH  - Endothelium, Vascular/*drug effects
MH  - Fibroblast Growth Factor 2/metabolism
MH  - Humans
MH  - Lymphokines/metabolism
MH  - Microscopy, Fluorescence
MH  - Molecular Sequence Data
MH  - Muscle, Smooth, Vascular/drug effects
MH  - Neovascularization, Physiologic/*drug effects
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Tumor Necrosis Factors
MH  - Vascular Endothelial Growth Factor A
MH  - Vascular Endothelial Growth Factors
EDAT- 1999/03/20 00:00
MHDA- 1999/03/20 00:01
CRDT- 1999/03/20 00:00
PHST- 1999/03/20 00:00 [pubmed]
PHST- 1999/03/20 00:01 [medline]
PHST- 1999/03/20 00:00 [entrez]
AID - 10.1074/jbc.274.13.8455 [doi]
PST - ppublish
SO  - J Biol Chem. 1999 Mar 26;274(13):8455-9. doi: 10.1074/jbc.274.13.8455.