PMID- 10084299
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20220318
IS  - 0022-202X (Print)
IS  - 0022-202X (Linking)
VI  - 112
IP  - 3
DP  - 1999 Mar
TI  - A susceptibility locus for epidermodysplasia verruciformis, an abnormal
      predisposition to infection with the oncogenic human papillomavirus type 5, maps 
      to chromosome 17qter in a region containing a psoriasis locus.
PG  - 259-63
AB  - Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by an
      abnormal susceptibility to infection with a specific group of related human
      papillomavirus (HPV) genotypes, including the oncogenic HPV5 associated with the 
      skin carcinomas developing in about half of EV patients. EV is usually considered
      as an autosomal recessive condition. Taking EV as a model to identify a locus
      underlying the susceptibility to HPV infections, we performed a genome-wide
      search for linkage with 255 microsatellite genetic markers in three
      consanguineous EV families comprising six patients, using the homozygosity
      mapping approach. Homozygosity restricted to affected individuals was observed
      for a marker of chromosome 17q (D17S784) in two families and a marker about 17
      centiMorgan (cM) distal (D17S1807) in the third family. Ten additional
      microsatellite markers spanning 29 cM in this region were analyzed. Two-point lod
      score values greater than 3 were obtained for four markers and multipoint linkage
      analysis yielded a maximum lod score of 10.17 between markers D17S939 and
      D17S802. Recombination events observed in two families allowed a candidate region
      for the EV susceptibility locus to be mapped to the 1 cM region defined by these 
      two markers. The EV locus (named EV1) is included in the 17qter region recently
      found to contain a dominant locus for the susceptibility to familial psoriasis.
      It has been shown that patients suffering from psoriasis are likely to constitute
      the reservoir of HPV5. It is thus tempting to speculate that distinct defects
      affecting the same gene may be involved in the two skin conditions.
FAU - Ramoz, N
AU  - Ramoz N
AD  - Unite Mixte Institut Pasteur/INSERM U190, Institut Pasteur, Paris, France.
FAU - Rueda, L A
AU  - Rueda LA
FAU - Bouadjar, B
AU  - Bouadjar B
FAU - Favre, M
AU  - Favre M
FAU - Orth, G
AU  - Orth G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
SB  - IM
MH  - *Chromosome Mapping
MH  - Chromosomes, Human, Pair 17/*genetics
MH  - Consanguinity
MH  - Epidermodysplasia Verruciformis/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Haplotypes
MH  - Homozygote
MH  - Humans
MH  - Lod Score
MH  - Male
MH  - Microsatellite Repeats/genetics
MH  - Papillomaviridae/classification
MH  - Papillomavirus Infections/*genetics
MH  - Pedigree
MH  - Psoriasis/*genetics
EDAT- 1999/03/20 00:00
MHDA- 1999/03/20 00:01
CRDT- 1999/03/20 00:00
PHST- 1999/03/20 00:00 [pubmed]
PHST- 1999/03/20 00:01 [medline]
PHST- 1999/03/20 00:00 [entrez]
AID - 10.1046/j.1523-1747.1999.00536.x [doi]
AID - S0022-202X(15)40410-5 [pii]
PST - ppublish
SO  - J Invest Dermatol. 1999 Mar;112(3):259-63. doi: 10.1046/j.1523-1747.1999.00536.x.