PMID- 10083736
OWN - NLM
STAT- MEDLINE
DCOM- 19990407
LR  - 20071115
IS  - 1434-5161 (Print)
IS  - 1434-5161 (Linking)
VI  - 44
IP  - 2
DP  - 1999
TI  - Isolation and characterization of a novel serine threonine kinase gene on
      chromosome 3p22-21.3.
PG  - 116-20
AB  - Through large-scale DNA sequencing of a genomic region on chromosome 3p22-p21.3, 
      we isolated a novel gene encoding a 527-amino-acid protein. Its 18 exons spanned 
      a genomic region of about 90 kilobases, and the 4536-nucleotide cDNA contained an
      open reading frame of 1581 base pairs. The gene was expressed in all 16 human
      tissues examined by Northern blotting. The amino acid sequence of the predicted
      protein was 39% identical to that of human SOK1 (Ste20/oxidant stress response
      kinase-1), a molecule that is activated by oxidative stress. In view of its
      significant similarity to SOK1, we suspect that the novel gene, which we named
      OSR1, is a member of the SOK family of kinases in terms of function.
FAU - Tamari, M
AU  - Tamari M
AD  - Laboratory of Molecular Medicine, University of Tokyo, Japan.
      yusuke@ims.u-tokyo.ac.jp
FAU - Daigo, Y
AU  - Daigo Y
FAU - Nakamura, Y
AU  - Nakamura Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
RN  - 0 (DNA, Complementary)
RN  - EC 2.7.1.- (OXSR1 protein, human)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 3
MH  - Cloning, Molecular
MH  - DNA, Complementary
MH  - Exons
MH  - Humans
MH  - Introns
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single-Stranded Conformational
MH  - Protein-Serine-Threonine Kinases/*genetics
MH  - Sequence Homology, Amino Acid
EDAT- 1999/03/20 00:00
MHDA- 1999/03/20 00:01
CRDT- 1999/03/20 00:00
PHST- 1999/03/20 00:00 [pubmed]
PHST- 1999/03/20 00:01 [medline]
PHST- 1999/03/20 00:00 [entrez]
AID - 10.1007/s100380050121 [doi]
PST - ppublish
SO  - J Hum Genet. 1999;44(2):116-20. doi: 10.1007/s100380050121.