PMID- 10079513
OWN - NLM
STAT- MEDLINE
DCOM- 19990329
LR  - 20090929
IS  - 0192-253X (Print)
IS  - 0192-253X (Linking)
VI  - 24
IP  - 1-2
DP  - 1999
TI  - Connexin45 (alpha 6) expression delineates an extended conduction system in the
      embryonic and mature rodent heart.
PG  - 82-90
AB  - We previously demonstrated that alpha 6 (Cx45), one of the three connexins of the
      mammalian myocardium, is preferentially expressed in the peripheral portion of
      the ventricular conduction system in rats and mice. Here we report that alpha 6
      is also prominently immunolocalized in the atrioventricular node and His bundle
      of these species. The distribution of immunolocalized alpha 6 reveals that the
      node and bundle form part of an extended central conductive network
      circumscribing the AV and outflow junctional regions of the fetal, and less
      continuously, the adult heart. Of the three cardiac connexins, alpha 6 is the
      isoform most continuously expressed by conduction tissues, and may thus account
      for the recently reported viability of the alpha 5 (Cx40) knockout mouse. It is
      concluded that alpha 6 expression is a defining feature of the heterogenous
      tissues comprising the atrioventricular conduction system of the rodent heart.
FAU - Coppen, S R
AU  - Coppen SR
AD  - National Heart and Lung Institute, Imperial College School of Medicine, Royal
      Brompton Hospital, London, England.
FAU - Severs, N J
AU  - Severs NJ
FAU - Gourdie, R G
AU  - Gourdie RG
LA  - eng
GR  - RGG-HL56728/HL/NHLBI NIH HHS/United States
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Dev Genet
JT  - Developmental genetics
JID - 7909963
RN  - 0 (Connexins)
RN  - 0 (connexin 40)
RN  - 0 (connexin 46)
SB  - IM
MH  - Animals
MH  - Atrioventricular Node/*chemistry/embryology
MH  - Bundle of His/*chemistry/embryology
MH  - Connexins/*analysis
MH  - Fetal Heart/*chemistry
MH  - Fluorescent Antibody Technique
MH  - Mice
MH  - Microscopy, Confocal
MH  - Myocardium/*chemistry
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 1999/03/18 03:02
MHDA- 2000/06/20 09:00
CRDT- 1999/03/18 03:02
PHST- 1999/03/18 03:02 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/03/18 03:02 [entrez]
AID - 10.1002/(SICI)1520-6408(1999)24:1/2<82::AID-DVG9>3.0.CO;2-1 [pii]
AID - 10.1002/(SICI)1520-6408(1999)24:1/2<82::AID-DVG9>3.0.CO;2-1 [doi]
PST - ppublish
SO  - Dev Genet. 1999;24(1-2):82-90. doi:
      10.1002/(SICI)1520-6408(1999)24:1/2<82::AID-DVG9>3.0.CO;2-1.