PMID- 10079287
OWN - NLM
STAT- MEDLINE
DCOM- 19990423
LR  - 20190831
IS  - 0093-7711 (Print)
IS  - 0093-7711 (Linking)
VI  - 49
IP  - 4
DP  - 1999 Apr
TI  - Molecular cloning, characterization, and chromosomal localization of the mouse
      homologue of CD84, a member of the CD2 family of cell surface molecules.
PG  - 249-55
AB  - CD84 is a member of the immunoglobulin gene superfamily (IgSF) with two Ig-like
      domains expressed primarily on B lymphocytes and macrophages. Here we describe
      the cloning of the mouse homologue of human CD84. Mouse CD84 cDNA clones were
      isolated from a macrophage library. The nucleotide sequence of mouse CD84 was
      shown to include an open reading frame encoding a putative 329 amino acid protein
      composed of a 21 amino acid leader peptide, two extracellular immunoglobulin
      (Ig)-like domains, a hydrophobic transmembrane region, and an 87 amino acid
      cytoplasmic domain. Mouse CD84 shares 57.3% amino acid sequence identity (88.7%, 
      considering conservative amino acid substitutions) with the human homologue.
      Chromosome localization studies mapped the mouse CD84 gene to distal chromosome 1
      adjacent to the gene for Ly-9, placing it close to the region where other members
      of the CD2 IgSF (CD48 and 2B4) have been mapped. Northern blot analysis revealed 
      that the expression of mouse CD84 was predominantly restricted to hematopoietic
      tissues. Two species of mRNA of 3.6 kilobases (kb) and 1.5 kb were observed. The 
      finding that the pattern of expression was restricted to the hematopoietic system
      and the conserved sequence of the mouse CD84 homologue suggests that the function
      of the CD84 glycoprotein may be similar in humans and mice.
FAU - de la Fuente, M A
AU  - de la Fuente MA
AD  - Immunology Unit, Department of Cellular Biology and Pathology, IDIBAPS, Medical
      School, University of Barcelona, C/Casanovas 143, Barcelona, Spain.
FAU - Tovar, V
AU  - Tovar V
FAU - Pizcueta, P
AU  - Pizcueta P
FAU - Nadal, M
AU  - Nadal M
FAU - Bosch, J
AU  - Bosch J
FAU - Engel, P
AU  - Engel P
LA  - eng
SI  - GENBANK/AF043445
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (Antigens, CD)
RN  - 0 (CD2 Antigens)
RN  - 0 (CD84 protein, human)
RN  - 0 (Cd84 protein, mouse)
RN  - 0 (DNA, Complementary)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Signaling Lymphocytic Activation Molecule Family)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antigens, CD/*genetics
MH  - Base Sequence
MH  - CD2 Antigens
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - DNA, Complementary
MH  - Humans
MH  - *Membrane Glycoproteins
MH  - Mice
MH  - Molecular Sequence Data
MH  - RNA, Messenger
MH  - Sequence Homology, Amino Acid
MH  - Signaling Lymphocytic Activation Molecule Family
EDAT- 1999/03/18 00:00
MHDA- 1999/03/18 00:01
CRDT- 1999/03/18 00:00
PHST- 1999/03/18 00:00 [pubmed]
PHST- 1999/03/18 00:01 [medline]
PHST- 1999/03/18 00:00 [entrez]
AID - 10.1007/s002510050490 [doi]
PST - ppublish
SO  - Immunogenetics. 1999 Apr;49(4):249-55. doi: 10.1007/s002510050490.