PMID- 10079256
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20181113
IS  - 0002-9440 (Print)
IS  - 0002-9440 (Linking)
VI  - 154
IP  - 3
DP  - 1999 Mar
TI  - Human ligands of the Notch receptor.
PG  - 785-94
AB  - During development, the Notch signaling pathway is essential for the appropriate 
      differentiation of many cell types in organisms across the phylogenetic scale,
      including humans. Notch signaling is also implicated in human diseases, including
      a leukemia and two hereditary syndromes known as Alagille and CADASIL. To
      generate tools for pursuing the role of the Notch pathway in human disease and
      development, we have cloned and analyzed the expression of three human homologues
      of the Notch ligands Delta and Serrate, human Jagged1 (HJ1), human Jagged2 (HJ2),
      and human Delta1 (H-Delta-1), and determined their chromosomal localizations. We 
      have also raised antibodies to HJ1, and used these antibodies in conjunction with
      in situ hybridization to examine the expression of these ligands in normal and
      cancerous cervical tissue. We find that, as reported previously for Notch, the
      ligands are up-regulated in certain neoplastic tissues. This observation is
      consistent with the notion that Notch signaling is an important element in these 
      pathogenic conditions, raising the possibility that modulation of Notch activity 
      could be used to influence the fate of the cells and offering a conceivable
      therapeutic avenue.
FAU - Gray, G E
AU  - Gray GE
AD  - Department of Cell Biology, Yale University School of Medicine, New Haven,
      Connecticut, USA.
FAU - Mann, R S
AU  - Mann RS
FAU - Mitsiadis, E
AU  - Mitsiadis E
FAU - Henrique, D
AU  - Henrique D
FAU - Carcangiu, M L
AU  - Carcangiu ML
FAU - Banks, A
AU  - Banks A
FAU - Leiman, J
AU  - Leiman J
FAU - Ward, D
AU  - Ward D
FAU - Ish-Horowitz, D
AU  - Ish-Horowitz D
FAU - Artavanis-Tsakonas, S
AU  - Artavanis-Tsakonas S
LA  - eng
SI  - GENBANK/AF003521
SI  - GENBANK/AF003522
SI  - GENBANK/U61276
GR  - 2R01NS26804-06A1/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (JAG1 protein, human)
RN  - 0 (JAG2 protein, human)
RN  - 0 (Jagged-1 Protein)
RN  - 0 (Jagged-2 Protein)
RN  - 0 (Membrane Proteins)
RN  - 0 (Proteins)
RN  - 0 (Serrate-Jagged Proteins)
RN  - 0 (delta protein)
SB  - AIM
SB  - IM
MH  - Amino Acid Sequence/genetics
MH  - Blotting, Northern
MH  - Calcium-Binding Proteins
MH  - Carrier Proteins/*genetics/metabolism
MH  - Cervix Uteri/metabolism
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - Female
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins
MH  - Intracellular Signaling Peptides and Proteins
MH  - Jagged-1 Protein
MH  - Jagged-2 Protein
MH  - Membrane Proteins/*genetics/metabolism
MH  - Molecular Sequence Data
MH  - Proteins/*genetics/metabolism
MH  - Reference Values
MH  - Serrate-Jagged Proteins
MH  - Uterine Cervical Neoplasms/metabolism
PMC - PMC1866435
EDAT- 1999/03/18 00:00
MHDA- 1999/03/18 00:01
CRDT- 1999/03/18 00:00
PHST- 1999/03/18 00:00 [pubmed]
PHST- 1999/03/18 00:01 [medline]
PHST- 1999/03/18 00:00 [entrez]
AID - S0002-9440(10)65325-4 [pii]
AID - 10.1016/S0002-9440(10)65325-4 [doi]
PST - ppublish
SO  - Am J Pathol. 1999 Mar;154(3):785-94. doi: 10.1016/S0002-9440(10)65325-4.