PMID- 10079223
OWN - NLM
STAT- MEDLINE
DCOM- 19990601
LR  - 20061115
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 126
IP  - 8
DP  - 1999 Apr
TI  - The flat-top gene is required for the expansion and regionalization of the
      telencephalic primordium.
PG  - 1601-9
AB  - The telencephalic vesicles form in the mouse embryo by the expansion of precursor
      regions in the anterior neural tube. Once the vesicles have formed, discrete
      dorsal and ventral territories can be recognized that later give rise to cortical
      and subcortical structures, respectively. To investigate the mechanisms that
      regulate the expansion and regionalization of the telencephalon, we have carried 
      out a screen to identify recessive mutations that disrupt these events. We
      isolated a mouse mutant in which an early and critical step in development of the
      telencephalic vesicles is disrupted. Telencephalic primordia are present in
      flat-top embryos but they fail to progress to form the telencephalic vesicles. An
      increased rate of proliferation in the forebrain neurectoderm that accompanies
      telencephalic expansion in wild-type embryos fails to occur in flat-top embryos. 
      Regionalization events that would normally take place during expansion of the
      primordia also fail to occur. Thus the phenotype of the flat-top mouse reveals
      that outgrowth of the telencephalic vesicles and their regionalization are
      coupled processes.
FAU - Hentges, K
AU  - Hentges K
AD  - Department of Genetics, Box 3568, Duke University Medical Centre, Durham, NC
      27710, USA.
FAU - Thompson, K
AU  - Thompson K
FAU - Peterson, A
AU  - Peterson A
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (FGF8 protein, human)
RN  - 0 (Fgf8 protein, mouse)
RN  - 148997-75-5 (Fibroblast Growth Factor 8)
RN  - 62031-54-3 (Fibroblast Growth Factors)
SB  - IM
MH  - Animals
MH  - Chromosome Mapping
MH  - Embryonic and Fetal Development/genetics
MH  - Female
MH  - Fibroblast Growth Factor 8
MH  - Fibroblast Growth Factors/physiology
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Phenotype
MH  - Telencephalon/*embryology
EDAT- 1999/03/18 00:00
MHDA- 1999/03/18 00:01
CRDT- 1999/03/18 00:00
PHST- 1999/03/18 00:00 [pubmed]
PHST- 1999/03/18 00:01 [medline]
PHST- 1999/03/18 00:00 [entrez]
PST - ppublish
SO  - Development. 1999 Apr;126(8):1601-9.