PMID- 10079193
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20061115
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 256
IP  - 2
DP  - 1999 Mar 16
TI  - Changes in caspase expression in Alzheimer's disease: comparison with development
      and aging.
PG  - 381-4
AB  - Changes in caspase-2 and -3 protein levels in Alzheimer's disease (AD) brains
      were assessed in comparison with their expression in development and aging. The
      protein levels of caspase-2 and -3 were significantly increased in AD brains,
      caspase-2 in the particulate fraction and caspase-3 in both the cytosolic and
      particulate fractions, compared with controls. Immunoblot analysis of brain
      extracts from embryonic day 19 (E19) to postnatal 96-week-old rats indicated that
      caspase-3 levels were high from E19 to 2 weeks, while caspase-2 remained high
      from 4 to 96 weeks, indicating that the expression of caspase-2 and -3 is
      differentially regulated during development and aging. These results suggest that
      caspase-2 and -3 are upregulated in AD and that the changes in AD are different
      from those observed in senescent brains.
CI  - Copyright 1999 Academic Press.
FAU - Shimohama, S
AU  - Shimohama S
AD  - Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto,
      Sakyoku, 606, Japan. i53367@sakura.kudpc.kyoto-u.ac.jp
FAU - Tanino, H
AU  - Tanino H
FAU - Fujimoto, S
AU  - Fujimoto S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Enzyme Precursors)
RN  - EC 3.4.22.- (CASP3 protein, human)
RN  - EC 3.4.22.- (Casp3 protein, rat)
RN  - EC 3.4.22.- (Caspase 2)
RN  - EC 3.4.22.- (Caspase 3)
RN  - EC 3.4.22.- (Caspases)
SB  - IM
MH  - Aged
MH  - Aging/*metabolism
MH  - Alzheimer Disease/*enzymology
MH  - Animals
MH  - Blotting, Western
MH  - Caspase 2
MH  - Caspase 3
MH  - Caspases/genetics/*metabolism
MH  - Cerebral Cortex/embryology/*enzymology
MH  - Cytosol/enzymology
MH  - Enzyme Precursors/genetics/metabolism
MH  - Female
MH  - Gene Expression Regulation, Developmental
MH  - *Gene Expression Regulation, Enzymologic
MH  - Humans
MH  - Male
MH  - Matched-Pair Analysis
MH  - Molecular Weight
MH  - Rats
MH  - Rats, Wistar
MH  - Solubility
MH  - Up-Regulation
EDAT- 1999/03/18 00:00
MHDA- 1999/03/18 00:01
CRDT- 1999/03/18 00:00
PHST- 1999/03/18 00:00 [pubmed]
PHST- 1999/03/18 00:01 [medline]
PHST- 1999/03/18 00:00 [entrez]
AID - S0006-291X(99)90344-3 [pii]
AID - 10.1006/bbrc.1999.0344 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 Mar 16;256(2):381-4. doi:
      10.1006/bbrc.1999.0344.