PMID- 10077617
OWN - NLM
STAT- MEDLINE
DCOM- 19990520
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 6
DP  - 1999 Mar 16
TI  - Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes.
PG  - 2949-51
AB  - The TCL1 oncogene on human chromosome 14q32.1 is involved in the development of T
      cell leukemia in humans. Its expression in these leukemias is activated by
      chromosomal translocations and inversions at 14q32.1. Here we report the
      isolation and characterization of a new member of the TCL1 gene family, TCL1b,
      located approximately 16 kb centromeric of TCL1. The 1.2-kb TCL1b cDNA encodes a 
      14-kDa protein of 128 aa and shows 60% similarity to Tcl1. Expression profiles of
      TCL1 and TCL1b genes are very similar: both genes are expressed at very low
      levels in normal bone marrow and peripheral lymphocytes but are activated in T
      cell leukemia by rearrangements of the 14q32.1 region. Thus, translocations and
      inversions at 14q32. 1 in T cell malignancies involve two oncogenes.
FAU - Pekarsky, Y
AU  - Pekarsky Y
AD  - Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
FAU - Hallas, C
AU  - Hallas C
FAU - Isobe, M
AU  - Isobe M
FAU - Russo, G
AU  - Russo G
FAU - Croce, C M
AU  - Croce CM
LA  - eng
SI  - GENBANK/AF110465
SI  - GENBANK/AF110466
SI  - GENBANK/AF110467
GR  - CA39880/CA/NCI NIH HHS/United States
GR  - CA51083/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (TCL1A protein, human)
RN  - 0 (TCL1B protein, human)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Amino Acid Sequence
MH  - *Chromosome Inversion
MH  - *Chromosomes, Human, Pair 14
MH  - DNA-Binding Proteins/*genetics
MH  - Humans
MH  - Leukemia, T-Cell/*genetics
MH  - Molecular Sequence Data
MH  - *Oncogene Proteins
MH  - *Oncogenes
MH  - *Proto-Oncogene Proteins
MH  - Sequence Alignment
MH  - Transcription Factors/*genetics
MH  - *Translocation, Genetic
PMC - PMC15875
EDAT- 1999/03/17 00:00
MHDA- 1999/03/17 00:01
CRDT- 1999/03/17 00:00
PHST- 1999/03/17 00:00 [pubmed]
PHST- 1999/03/17 00:01 [medline]
PHST- 1999/03/17 00:00 [entrez]
AID - 10.1073/pnas.96.6.2949 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2949-51. doi: 10.1073/pnas.96.6.2949.