PMID- 10077563
OWN - NLM
STAT- MEDLINE
DCOM- 19990520
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 6
DP  - 1999 Mar 16
TI  - Unique forms of human and mouse nuclear receptor corepressor SMRT.
PG  - 2639-44
AB  - Nuclear hormone receptors have been shown to repress transcription in the absence
      of ligand. This repression is mediated by a corepressor complex that contains the
      Sin3A protein and histone deacetylases (HDAC1 and 2). Studies by several groups
      demonstrate that this complex is recruited to nuclear receptors through the
      highly related corepressors SMRT (silencing mediator of retinoid acid and thyroid
      hormone receptor) and N-CoR (nuclear receptor corepressor). We describe here the 
      cloning, characterization, and chromosomal mapping of forms of human and mouse
      SMRT that includes a 1,000-aa extension, which reveals striking homology to the
      amino terminus of N-CoR. Structure and function studies of wild-type and natural 
      splicing variants suggest the presence of 3-4 amino terminal domains that repress
      in a cooperative as well as mechanistically distinct fashion.
FAU - Ordentlich, P
AU  - Ordentlich P
AD  - Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010
      North Torrey Pines Road, La Jolla, CA 92037, USA.
FAU - Downes, M
AU  - Downes M
FAU - Xie, W
AU  - Xie W
FAU - Genin, A
AU  - Genin A
FAU - Spinner, N B
AU  - Spinner NB
FAU - Evans, R M
AU  - Evans RM
LA  - eng
SI  - GENBANK/AF113001
SI  - GENBANK/AF113002
SI  - GENBANK/AF113003
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (NCOR2 protein, human)
RN  - 0 (Ncor2 protein, mouse)
RN  - 0 (Nuclear Receptor Co-Repressor 2)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Repressor Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 12
MH  - Cloning, Molecular
MH  - DNA, Complementary/analysis/genetics
MH  - DNA-Binding Proteins/*genetics
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nuclear Receptor Co-Repressor 2
MH  - Receptors, Cytoplasmic and Nuclear/*genetics
MH  - Repressor Proteins/*genetics
MH  - Sequence Alignment
MH  - Sequence Analysis
PMC - PMC15821
EDAT- 1999/03/17 00:00
MHDA- 1999/03/17 00:01
CRDT- 1999/03/17 00:00
PHST- 1999/03/17 00:00 [pubmed]
PHST- 1999/03/17 00:01 [medline]
PHST- 1999/03/17 00:00 [entrez]
AID - 10.1073/pnas.96.6.2639 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2639-44. doi: 10.1073/pnas.96.6.2639.