PMID- 10076889
OWN - NLM
STAT- MEDLINE
DCOM- 19990517
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 260
IP  - 3
DP  - 1999 Feb 5
TI  - Expression of gicerin, a novel cell adhesion molecule, is upregulated in the
      astrocytes after hypoglossal nerve injury in rats.
PG  - 149-52
AB  - Gicerin is an integral membrane glycoprotein which mediates cell-cell and
      cell-extracellular matrix (ECM) interactions in the nervous system. We studied
      gicerin expression in the hypoglossal nucleus post transection using in situ
      hybridization and immunocytochemistry. We found that hypoglossal nerve injury
      resulted in a significant increase in gicerin expression. Its expression levels
      reached peak values in reactive astrocytes surrounding axotomized motoneurons of 
      the ipsilateral hypoglossal nucleus 14 days after hypoglossal nerve injury. The
      results indicate that gicerin is up-regulated during nerve regeneration,
      suggesting that gicerin expressed in the reactive astrocytes might be involved in
      the processes of nerve regeneration.
FAU - Li, B S
AU  - Li BS
AD  - Department of Pharmacology I, Osaka University Medicine School, Suita, Japan.
FAU - Su, Q N
AU  - Su QN
FAU - Kiyama, H
AU  - Kiyama H
FAU - Miki, N
AU  - Miki N
FAU - Robinow, D R
AU  - Robinow DR
FAU - Zhang, L
AU  - Zhang L
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Avian Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neural Cell Adhesion Molecules)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Astrocytes/*metabolism
MH  - *Avian Proteins
MH  - Carrier Proteins/*biosynthesis/genetics
MH  - Cell Adhesion Molecules/*biosynthesis/genetics
MH  - Glial Fibrillary Acidic Protein/biosynthesis
MH  - Hypoglossal Nerve/cytology/metabolism
MH  - *Hypoglossal Nerve Injuries
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Male
MH  - Nerve Regeneration/physiology
MH  - Nerve Tissue Proteins/*biosynthesis/genetics
MH  - Neural Cell Adhesion Molecules/*biosynthesis/genetics
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Rats, Wistar
MH  - Up-Regulation/*physiology
EDAT- 1999/03/17 00:00
MHDA- 1999/03/17 00:01
CRDT- 1999/03/17 00:00
PHST- 1999/03/17 00:00 [pubmed]
PHST- 1999/03/17 00:01 [medline]
PHST- 1999/03/17 00:00 [entrez]
AID - S0304394098009793 [pii]
AID - 10.1016/s0304-3940(98)00979-3 [doi]
PST - ppublish
SO  - Neurosci Lett. 1999 Feb 5;260(3):149-52. doi: 10.1016/s0304-3940(98)00979-3.