PMID- 10075849
OWN - NLM
STAT- MEDLINE
DCOM- 19990506
LR  - 20081121
IS  - 0012-1606 (Print)
IS  - 0012-1606 (Linking)
VI  - 208
IP  - 1
DP  - 1999 Apr 1
TI  - Hox gene expression in limbs: colinearity by opposite regulatory controls.
PG  - 157-65
AB  - Genes of the HoxD complex have a crucial role in the morphogenesis of vertebrate 
      limbs. During development, their functional domains are colinear with their
      genomic positions within the HoxD cluster such that Hoxd13 and Hoxd12 are
      necessary for digit development, whereas Hoxd11 and Hoxd10 are involved in making
      forearms. Mutational analyses of these genes have demonstrated their importance
      and illustrated the requirement for a precise control of their expression during 
      early limb morphogenesis. To study the nature of this control, we have scanned
      the posterior part of the HoxD complex with a targeted reporter transgene and
      analyzed the response of this foreign promoter to limb regulatory influences. The
      results suggest that this regulation is achieved through the opposite effects of 
      two enhancer elements which would compete with each other for interacting with
      nearby-located promoters. The physical position of a given gene within this
      genomic interval of opposite regulations might thus determine its final
      expression pattern. This model provides a conceptual link between the morphology 
      of the future limb and the genetic organization of the Hox gene cluster, a
      translation of a genomic context into a morphogenetic topology.
CI  - Copyright 1999 Academic Press.
FAU - Herault, Y
AU  - Herault Y
AD  - Department of Zoology and Animal Biology, University of Geneva, Sciences III,
      Quai Ernest Ansermet 30, Geneva 4, 1211, Switzerland.
FAU - Beckers, J
AU  - Beckers J
FAU - Gerard, M
AU  - Gerard M
FAU - Duboule, D
AU  - Duboule D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Hoxd10 protein, mouse)
RN  - 0 (Hoxd4 protein, mouse)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
RN  - 0 (Zebrafish Proteins)
RN  - 0 (hoxd10a protein, zebrafish)
RN  - EC 2.7.2.3 (Phosphoglycerate Kinase)
SB  - IM
MH  - Animals
MH  - Embryonic and Fetal Development
MH  - Enhancer Elements, Genetic/genetics
MH  - Extremities/*embryology/growth & development
MH  - Gene Expression Regulation, Developmental/genetics
MH  - Genes, Homeobox/*genetics
MH  - Homeodomain Proteins/genetics
MH  - In Situ Hybridization
MH  - Mice
MH  - Morphogenesis
MH  - Phosphoglycerate Kinase/genetics
MH  - Promoter Regions, Genetic/genetics
MH  - RNA, Messenger/metabolism
MH  - Transcription Factors/genetics
MH  - Transgenes/genetics
MH  - *Zebrafish Proteins
EDAT- 1999/03/17 00:00
MHDA- 1999/03/17 00:01
CRDT- 1999/03/17 00:00
PHST- 1999/03/17 00:00 [pubmed]
PHST- 1999/03/17 00:01 [medline]
PHST- 1999/03/17 00:00 [entrez]
AID - S0012-1606(98)99179-5 [pii]
AID - 10.1006/dbio.1998.9179 [doi]
PST - ppublish
SO  - Dev Biol. 1999 Apr 1;208(1):157-65. doi: 10.1006/dbio.1998.9179.