PMID- 10074428
OWN - NLM
STAT- MEDLINE
DCOM- 19990422
LR  - 20111117
IS  - 0960-9822 (Print)
IS  - 0960-9822 (Linking)
VI  - 9
IP  - 4
DP  - 1999 Feb 25
TI  - Identification of a new member of the tumor necrosis factor family and its
      receptor, a human ortholog of mouse GITR.
PG  - 215-8
AB  - The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies
      regulate diverse biological functions, including cell proliferation,
      differentiation, and survival [1] [2] [3]. We have identified a new TNF-related
      ligand, designated human GITR ligand (hGITRL), and its human receptor (hGITR), an
      ortholog of the recently discovered murine glucocorticoid-induced TNFR-related
      (mGITR) protein [4]. The hGITRL gene mapped to chromosome 1q23, near the gene for
      the TNF homolog Fas/CD95 ligand [5]. The hGITR gene mapped to chromosome 1p36,
      near a cluster of five genes encoding TNFR homologs [1] [6]. We found hGITRL mRNA
      in several peripheral tissues, and detected hGITRL protein on cultured vascular
      endothelial cells. The levels of hGITR mRNA in tissues were generally low; in
      peripheral blood T cells, however, antigen-receptor stimulation led to a
      substantial induction of hGITR transcripts. Cotransfection of hGITRL and hGITR in
      embryonic kidney 293 cells activated the anti-apoptotic transcription factor
      NF-kappaB, via a pathway that appeared to involve TNFR-associated factor 2
      (TRAF2) [7] and NF-kappaB-inducing kinase (NIK) [8]. Cotransfection of hGITRL and
      hGITR in Jurkat T leukemia cells inhibited antigen-receptor-induced cell death.
      Thus, hGITRL and hGITR may modulate T lymphocyte survival in peripheral tissues.
FAU - Gurney, A L
AU  - Gurney AL
AD  - Department of Molecular Biology Genentech Inc. 1 DNA Way South San Francisco
      California 94080 USA.
FAU - Marsters, S A
AU  - Marsters SA
FAU - Huang, R M
AU  - Huang RM
FAU - Pitti, R M
AU  - Pitti RM
FAU - Mark, D T
AU  - Mark DT
FAU - Baldwin, D T
AU  - Baldwin DT
FAU - Gray, A M
AU  - Gray AM
FAU - Dowd, A D
AU  - Dowd AD
FAU - Brush, A D
AU  - Brush AD
FAU - Heldens, A D
AU  - Heldens AD
FAU - Schow, A D
AU  - Schow AD
FAU - Goddard, A D
AU  - Goddard AD
FAU - Wood, W I
AU  - Wood WI
FAU - Baker, K P
AU  - Baker KP
FAU - Godowski, P J
AU  - Godowski PJ
FAU - Ashkenazi, A
AU  - Ashkenazi A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Curr Biol
JT  - Current biology : CB
JID - 9107782
RN  - 0 (Glucocorticoid-Induced TNFR-Related Protein)
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Recombinant Proteins)
RN  - 0 (TNF Receptor-Associated Factor 2)
RN  - 0 (TNFRSF18 protein, human)
RN  - 0 (Tnfrsf18 protein, mouse)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cell Line
MH  - Cells, Cultured
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 1
MH  - Endothelium, Vascular/metabolism
MH  - Gene Expression Regulation
MH  - Glucocorticoid-Induced TNFR-Related Protein
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - Proteins/metabolism
MH  - RNA, Messenger/analysis
MH  - Receptors, Nerve Growth Factor/chemistry/*genetics/physiology
MH  - Receptors, Tumor Necrosis Factor/chemistry/*genetics/physiology
MH  - Recombinant Proteins/biosynthesis
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
MH  - TNF Receptor-Associated Factor 2
MH  - *Transcription, Genetic
MH  - Transfection
MH  - Tumor Necrosis Factor-alpha/chemistry/*genetics
EDAT- 1999/03/13 00:00
MHDA- 1999/03/13 00:01
CRDT- 1999/03/13 00:00
PHST- 1999/03/13 00:00 [pubmed]
PHST- 1999/03/13 00:01 [medline]
PHST- 1999/03/13 00:00 [entrez]
AID - S0960-9822(99)80093-1 [pii]
PST - ppublish
SO  - Curr Biol. 1999 Feb 25;9(4):215-8.