PMID- 10073940
OWN - NLM
STAT- MEDLINE
DCOM- 19990401
LR  - 20190619
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 283
IP  - 5408
DP  - 1999 Mar 12
TI  - Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of
      axin.
PG  - 1739-42
AB  - Wnt/Wingless directs many cell fates during development. Wnt/Wingless signaling
      increases the amount of beta-catenin/Armadillo, which in turn activates gene
      transcription. Here the Drosophila protein D-Axin was shown to interact with
      Armadillo and D-APC. Mutation of d-axin resulted in the accumulation of
      cytoplasmic Armadillo and one of the Wingless target gene products, Distal-less. 
      Ectopic expression of d-axin inhibited Wingless signaling. Hence, D-Axin
      negatively regulates Wingless signaling by down-regulating the level of
      Armadillo. These results establish the importance of the Axin family of proteins 
      in Wnt/Wingless signaling in Drosophila.
FAU - Hamada, F
AU  - Hamada F
AD  - Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka
      University, 3-1 Yamadaoka, Suita 565-0871, Japan.
FAU - Tomoyasu, Y
AU  - Tomoyasu Y
FAU - Takatsu, Y
AU  - Takatsu Y
FAU - Nakamura, M
AU  - Nakamura M
FAU - Nagai, S
AU  - Nagai S
FAU - Suzuki, A
AU  - Suzuki A
FAU - Fujita, F
AU  - Fujita F
FAU - Shibuya, H
AU  - Shibuya H
FAU - Toyoshima, K
AU  - Toyoshima K
FAU - Ueno, N
AU  - Ueno N
FAU - Akiyama, T
AU  - Akiyama T
LA  - eng
SI  - GENBANK/AF086811
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (APC protein, Drosophila)
RN  - 0 (ARM protein, Drosophila)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Adenomatous Polyposis Coli Protein)
RN  - 0 (Armadillo Domain Proteins)
RN  - 0 (Axin Protein)
RN  - 0 (Axn protein, Drosophila)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Insect Proteins)
RN  - 0 (Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (Wnt1 Protein)
RN  - 0 (distal-less protein, insect)
RN  - 0 (wg protein, Drosophila)
SB  - IM
MH  - *Adaptor Proteins, Signal Transducing
MH  - Adenomatous Polyposis Coli Protein
MH  - Animals
MH  - Armadillo Domain Proteins
MH  - Axin Protein
MH  - Body Patterning
MH  - Carrier Proteins/chemistry/genetics/*metabolism
MH  - Chromosome Mapping
MH  - Cytoplasm/metabolism
MH  - Cytoskeletal Proteins/metabolism
MH  - Down-Regulation
MH  - Drosophila/*embryology/genetics/metabolism
MH  - *Drosophila Proteins
MH  - Embryo, Nonmammalian/metabolism
MH  - Extremities/embryology
MH  - Gene Expression Regulation, Developmental
MH  - Genes, Insect
MH  - Homeodomain Proteins/genetics/metabolism
MH  - In Situ Hybridization
MH  - Insect Proteins/genetics/metabolism
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Phenotype
MH  - Proteins/chemistry/genetics/*metabolism
MH  - Proto-Oncogene Proteins/*metabolism
MH  - Recombinant Fusion Proteins/metabolism
MH  - *Repressor Proteins
MH  - *Signal Transduction
MH  - *Trans-Activators
MH  - *Transcription Factors
MH  - Wings, Animal/embryology/metabolism
MH  - Wnt1 Protein
EDAT- 1999/03/12 00:00
MHDA- 1999/03/12 00:01
CRDT- 1999/03/12 00:00
PHST- 1999/03/12 00:00 [pubmed]
PHST- 1999/03/12 00:01 [medline]
PHST- 1999/03/12 00:00 [entrez]
AID - 10.1126/science.283.5408.1739 [doi]
PST - ppublish
SO  - Science. 1999 Mar 12;283(5408):1739-42. doi: 10.1126/science.283.5408.1739.