PMID- 10072791
OWN - NLM
STAT- MEDLINE
DCOM- 19990607
LR  - 20190909
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 80
IP  - 2
DP  - 1999 Feb
TI  - Fjx1, the murine homologue of the Drosophila four-jointed gene, codes for a
      putative secreted protein expressed in restricted domains of the developing and
      adult brain.
PG  - 213-7
AB  - The Drosophila gene four jointed (fj) codes for a secreted or cell surface
      protein important for growth and differentiation of legs and wings and for proper
      development of the eyes. Here we report the cloning of the mouse four-jointed
      gene (fjx1) and its pattern of expression in the brain during embryogenesis and
      in the adult. In the neural plate, fjx1 is expressed in the presumptive forebrain
      and midbrain, and in rhombomere 4, however a small rostral/medial area of the
      forebrain primordium is devoid of expression. Expression of fjx1 in the neural
      tube can be divided into three phases. (1) In the embryonic brain fjx1 is
      expressed in two patches of neuroepithelium: in the midbrain tectum and the
      telencephalic vesicles. (2) In fetal and early postnatal brain fjx1 is expressed 
      mainly by the primordia of layered telencephalic structures: cortex (ventricular 
      layer and cortical plate), olfactory bulb (subependymal layer and in the mitral
      cell layer). In addition expression is observed in the superior colliculus. (3)
      In the adult, fjx1 is expressed by neurones evenly distributed in the
      telencephalon (isocortex, striatum, hippocampus, olfactory bulb, piriform
      cortex), in the Purkinje cell layer of the cerebellum, and numerous medullary
      nuclei. In the embryo, strong expression can further be seen in the apical
      ectodermal ridge of fore- and hindlimbs and in the ectoderm of the branchial
      arches.
CI  - Copyright 1998 Elsevier Science Ireland Ltd.
FAU - Ashery-Padan, R
AU  - Ashery-Padan R
AD  - Max-Planck Institute of Biophysical Chemistry, Goettingen, D37077, Germany.
FAU - Alvarez-Bolado, G
AU  - Alvarez-Bolado G
FAU - Klamt, B
AU  - Klamt B
FAU - Gessler, M
AU  - Gessler M
FAU - Gruss, P
AU  - Gruss P
LA  - eng
SI  - GENBANK/AJ009634
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (DNA, Complementary)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Fetal Proteins)
RN  - 0 (Fjx1 protein, mouse)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (fj protein, Drosophila)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Brain/embryology/growth & development/*metabolism
MH  - DNA, Complementary/genetics
MH  - *Drosophila Proteins
MH  - Embryonic and Fetal Development/genetics
MH  - Fetal Proteins/biosynthesis/genetics/metabolism
MH  - *Gene Expression Regulation, Developmental
MH  - Membrane Glycoproteins/biosynthesis/*genetics/metabolism
MH  - Mice/embryology/*genetics/growth & development
MH  - Molecular Sequence Data
MH  - Morphogenesis/genetics
MH  - Nerve Tissue Proteins/biosynthesis/*genetics/metabolism
MH  - Organ Specificity
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
EDAT- 1999/03/12 00:00
MHDA- 1999/03/12 00:01
CRDT- 1999/03/12 00:00
PHST- 1999/03/12 00:00 [pubmed]
PHST- 1999/03/12 00:01 [medline]
PHST- 1999/03/12 00:00 [entrez]
AID - S0925477398002184 [pii]
AID - 10.1016/s0925-4773(98)00218-4 [doi]
PST - ppublish
SO  - Mech Dev. 1999 Feb;80(2):213-7. doi: 10.1016/s0925-4773(98)00218-4.