PMID- 10072786
OWN - NLM
STAT- MEDLINE
DCOM- 19990607
LR  - 20190909
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 80
IP  - 2
DP  - 1999 Feb
TI  - Expression of growth/differentiation factor 11, a new member of the BMP/TGFbeta
      superfamily during mouse embryogenesis.
PG  - 185-9
AB  - We have cloned and characterized a new member of the bone morphogenetic
      protein/transforming growth factor beta (BMP/TGFbeta) superfamily, growth
      differentiation factor 11 (Gdf11), from rat incisor pulp RNA by reverse
      transcription-polymerase chain reaction using degenerate primers. The mature
      carboxyl-terminal domain encoded by Gdf11 is most closely related to Gdf8, being 
      90% identical to the mouse gene. Northern blot analysis revealed Gdf11 is
      expressed in adult dental pulp and brain. In situ hybridization of sections and
      whole-mount embryos demonstrated Gdf11 is first strongly expressed in restricted 
      domains at 8.5 days post coitus (dpc) when it is highest in the tail bud. At 10.5
      dpc, it is expressed in the branchial arches, limb bud, tail bud and posterior
      dorsal neural tube. Later, it is expressed in terminally-differentiated
      odontoblasts, the nasal epithelium, retina and specific regions of the brain.
CI  - Copyright 1998 Elsevier Science Ireland Ltd.
FAU - Nakashima, M
AU  - Nakashima M
AD  - Department of Operative Dentistry and Endodontology, Faculty of Dentistry, Kyushu
      University, Fukuoka 812-82, Japan. nakashim@saturn.med.nyu.edu
FAU - Toyono, T
AU  - Toyono T
FAU - Akamine, A
AU  - Akamine A
FAU - Joyner, A
AU  - Joyner A
LA  - eng
SI  - GENBANK/AF092733
SI  - GENBANK/AF092734
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (Bone Morphogenetic Proteins)
RN  - 0 (Gdf11 protein, mouse)
RN  - 0 (Gdf11 protein, rat)
RN  - 0 (Growth Differentiation Factors)
SB  - IM
MH  - Animals
MH  - Bone Morphogenetic Proteins/*biosynthesis/genetics/physiology
MH  - Embryonic and Fetal Development/*genetics
MH  - *Gene Expression Regulation, Developmental
MH  - Growth Differentiation Factors
MH  - Mice
MH  - Morphogenesis
EDAT- 1999/03/12 00:00
MHDA- 1999/03/12 00:01
CRDT- 1999/03/12 00:00
PHST- 1999/03/12 00:00 [pubmed]
PHST- 1999/03/12 00:01 [medline]
PHST- 1999/03/12 00:00 [entrez]
AID - S0925477398002056 [pii]
AID - 10.1016/s0925-4773(98)00205-6 [doi]
PST - ppublish
SO  - Mech Dev. 1999 Feb;80(2):185-9. doi: 10.1016/s0925-4773(98)00205-6.