PMID- 10072784
OWN - NLM
STAT- MEDLINE
DCOM- 19990607
LR  - 20190909
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 80
IP  - 2
DP  - 1999 Feb
TI  - The Enhancer of split complex of Drosophila melanogaster harbors three classes of 
      Notch responsive genes.
PG  - 171-80
AB  - Many cell fate decisions in higher animals are based on intercellular 
      communication governed by the Notch signaling pathway. Developmental signals 
      received by the Notch receptor cause Suppressor of Hairless (Su(H)) mediated 
      transcription of target genes. In Drosophila, the majority of Notch target genes 
      known so far is located in the Enhancer of split complex (E(spl)-C), encoding 
      small basic helix-loop-helix (bHLH) proteins that presumably act as 
      transcriptional repressors. Here we show that the E(spl)-C contains three 
      additional Notch responsive, non-bHLH genes: m4 and ma are structurally related, 
      whilst m2 encodes a novel protein. All three genes depend on Su(H) for initiation 
      and/or maintenance of transcription. The two other non-bHLH genes within the 
      locus, m1 and m6, are unrelated to the Notch pathway: m1 might code for a 
      protease inhibitor of the Kazal family, and m6 for a novel peptide.
CI  - Copyright 1998 Elsevier Science Ireland Ltd.
FAU - Wurmbach, E
AU  - Wurmbach E
AD  - Universitat Hohenheim, Institut fur Genetik (240), 70593, Stuttgart, Germany.
FAU - Wech, I
AU  - Wech I
FAU - Preiss, A
AU  - Preiss A
LA  - eng
SI  - GENBANK/AJ010167
SI  - GENBANK/AJ010168
SI  - GENBANK/AJ011140
SI  - GENBANK/AJ012204
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (E(spl)mdelta-HLH protein, Drosophila)
RN  - 0 (Insect Proteins)
RN  - 0 (Macromolecular Substances)
RN  - 0 (Membrane Proteins)
RN  - 0 (N protein, Drosophila)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, Notch)
RN  - 0 (Repressor Proteins)
RN  - 0 (Su(H) protein, Drosophila)
RN  - 147445-78-1 (E(spl)m3-HLH protein, Drosophila)
RN  - 147445-79-2 (E(spl)mbeta-HLH protein, Drosophila)
RN  - 147445-80-5 (E(spl)mgamma-HLH protein, Drosophila)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Basic Helix-Loop-Helix Transcription Factors
MH  - DNA, Complementary/genetics
MH  - DNA-Binding Proteins/*genetics/*physiology
MH  - *Drosophila Proteins
MH  - Drosophila melanogaster/embryology/*genetics
MH  - Embryo, Nonmammalian/metabolism
MH  - Evolution, Molecular
MH  - *Gene Expression Regulation, Developmental
MH  - *Genes, Insect
MH  - Helix-Loop-Helix Motifs/genetics
MH  - Insect Proteins/*genetics/*physiology
MH  - Macromolecular Substances
MH  - Membrane Proteins/*physiology
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/genetics/physiology
MH  - Receptors, Notch
MH  - Repressor Proteins/genetics/physiology
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
EDAT- 1999/03/12 00:00
MHDA- 1999/03/12 00:01
CRDT- 1999/03/12 00:00
PHST- 1999/03/12 00:00 [pubmed]
PHST- 1999/03/12 00:01 [medline]
PHST- 1999/03/12 00:00 [entrez]
AID - S0925477398002123 [pii]
AID - 10.1016/s0925-4773(98)00212-3 [doi]
PST - ppublish
SO  - Mech Dev. 1999 Feb;80(2):171-80. doi: 10.1016/s0925-4773(98)00212-3.