PMID- 10072438
OWN - NLM
STAT- MEDLINE
DCOM- 19990429
LR  - 20190513
IS  - 0964-6906 (Print)
IS  - 0964-6906 (Linking)
VI  - 8
IP  - 4
DP  - 1999 Apr
TI  - Two novel genes in the center of the 11p15 imprinted domain escape genomic
      imprinting.
PG  - 683-90
AB  - We previously reported the isolation of a 2.5 Mb tumor-suppressing subchromosomal
      transferable fragment (STF) from human chromosome 11p15 and the identification of
      nine known genes and four novel genes within this STF. We now report the
      isolation of two novel cDNAs, designated here as TSSC4 and TSSC6
      (tumor-suppressing STF cDNA 4 and 6), located within the STF. TSSC4 and TSSC6
      encode predicted proteins of 329 and 290 amino acids, respectively, with no close
      similarity to previously reported proteins. TSSC4 and TSSC6 are both located in
      the center of a 1 Mb imprinted domain, which contains the imprinted genes TSSC3, 
      TSSC5, p57(KIP2), KVLQT1, ASCL2, IGF2 and H19. However, we found that neither
      TSSC4 nor TSSC6 was significantly imprinted in any of the fetal or
      extra-embryonic tissues examined. Based on this result, the imprinted gene domain
      of 11p15 appears to contain at least two imprinted subdomains, between which
      TSSC4 and TSSC6 substantially escape imprinting, due either to lack of initial
      silencing or to an early developmental relaxation of imprinting.
FAU - Lee, M P
AU  - Lee MP
AD  - Department of Medicine, Johns Hopkins University School of Medicine, 1064 Ross,
      720 Rutland Avenue, Baltimore, MD 21205, USA.
FAU - Brandenburg, S
AU  - Brandenburg S
FAU - Landes, G M
AU  - Landes GM
FAU - Adams, M
AU  - Adams M
FAU - Miller, G
AU  - Miller G
FAU - Feinberg, A P
AU  - Feinberg AP
LA  - eng
SI  - GENBANK/AF125568
SI  - GENBANK/AF125569
GR  - R01 CA054358/CA/NCI NIH HHS/United States
GR  - CA54358/CA/NCI NIH HHS/United States
GR  - CA65145/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Hum Mol Genet
JT  - Human molecular genetics
JID - 9208958
RN  - 0 (DNA, Complementary)
RN  - 0 (Membrane Proteins)
RN  - 0 (Proteins)
RN  - 0 (TSPAN32 protein, human)
RN  - 0 (TSSC4 protein, human)
RN  - 0 (Tetraspanins)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Cloning, Molecular
MH  - DNA, Complementary/chemistry/genetics
MH  - Female
MH  - Fetus/metabolism
MH  - Gene Expression Regulation, Developmental
MH  - Genes, Tumor Suppressor/*genetics
MH  - *Genomic Imprinting
MH  - Humans
MH  - Male
MH  - *Membrane Proteins
MH  - Molecular Sequence Data
MH  - Proteins/*genetics
MH  - RNA/genetics/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sequence Analysis, DNA
MH  - Tetraspanins
MH  - Tissue Distribution
MH  - *Tumor Suppressor Proteins
EDAT- 1999/03/11 00:00
MHDA- 1999/03/11 00:01
CRDT- 1999/03/11 00:00
PHST- 1999/03/11 00:00 [pubmed]
PHST- 1999/03/11 00:01 [medline]
PHST- 1999/03/11 00:00 [entrez]
AID - ddc077 [pii]
AID - 10.1093/hmg/8.4.683 [doi]
PST - ppublish
SO  - Hum Mol Genet. 1999 Apr;8(4):683-90. doi: 10.1093/hmg/8.4.683.