PMID- 10072381
OWN - NLM
STAT- MEDLINE
DCOM- 19990427
LR  - 20190516
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 13
IP  - 5
DP  - 1999 Mar 1
TI  - Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male
      and female meiosis.
PG  - 523-31
AB  - Members of the mammalian mismatch repair protein family of MutS and MutL homologs
      have been implicated in postreplicative mismatch correction and chromosome
      interactions during meiotic recombination. Here we demonstrate that mice carrying
      a disruption in MutS homolog Msh5 show a meiotic defect, leading to male and
      female sterility. Histological and cytological examination of prophase I stages
      in both sexes revealed an extended zygotene stage, characterized by impaired and 
      aberrant chromosome synapsis, that was followed by apoptotic cell death. Thus,
      murine Msh5 promotes synapsis of homologous chromosomes in meiotic prophase I.
FAU - de Vries, S S
AU  - de Vries SS
AD  - Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX
      Amsterdam, The Netherlands.
FAU - Baart, E B
AU  - Baart EB
FAU - Dekker, M
AU  - Dekker M
FAU - Siezen, A
AU  - Siezen A
FAU - de Rooij, D G
AU  - de Rooij DG
FAU - de Boer, P
AU  - de Boer P
FAU - te Riele, H
AU  - te Riele H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Msh5 protein, mouse)
RN  - 0 (Proteins)
SB  - IM
MH  - Animals
MH  - Base Pair Mismatch
MH  - Cell Cycle Proteins
MH  - Cell Line
MH  - DNA-Binding Proteins
MH  - Female
MH  - Infertility, Female/etiology
MH  - Infertility, Male/etiology
MH  - Male
MH  - Meiosis/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Oocytes
MH  - Proteins/genetics/*physiology
MH  - Spermatocytes/physiology
MH  - Synaptonemal Complex/physiology
PMC - PMC316502
EDAT- 1999/03/11 00:00
MHDA- 1999/03/11 00:01
CRDT- 1999/03/11 00:00
PHST- 1999/03/11 00:00 [pubmed]
PHST- 1999/03/11 00:01 [medline]
PHST- 1999/03/11 00:00 [entrez]
AID - 10.1101/gad.13.5.523 [doi]
PST - ppublish
SO  - Genes Dev. 1999 Mar 1;13(5):523-31. doi: 10.1101/gad.13.5.523.